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B7JPM2 (B7JPM2_BACC0) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylmalonate semialdehyde dehydrogenase [acylating] 2 HAMAP MF_01670
Short name=MMSA dehydrogenase 2 HAMAP MF_01670
Short name=MMSDH 2 HAMAP MF_01670
Short name=MSDH 2 HAMAP MF_01670
EC=1.2.1.27 HAMAP MF_01670
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating] 2 HAMAP MF_01670
Gene names
Name:mmsA2 EMBL ACK90845.1
Synonyms:iolA2 HAMAP MF_01670
Ordered Locus Names:BCAH820_2529
OrganismBacillus cereus (strain AH820) [Complete proteome] [HAMAP] EMBL ACK90845.1
Taxonomic identifier405535 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP MF_01670

Catalytic activity

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP MF_01670

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP MF_01670

Subunit structure

Homotetramer By similarity. HAMAP MF_01670

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily. HAMAP MF_01670

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding178 – 1825NAD By similarity HAMAP MF_01670

Sites

Active site2861Nucleophile By similarity HAMAP MF_01670
Binding site3861NAD By similarity HAMAP MF_01670

Sequences

Sequence LengthMass (Da)Tools
B7JPM2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 4D650C3AE2198B74

FASTA48753,111
        10         20         30         40         50         60 
MTVQTAQIVK NYIGGEWVES ISTKMEAVYN PATGEVIAQV PLSTKVDVEQ AVLAANEAFK 

        70         80         90        100        110        120 
SWSKTAVPKR ARILFKYQQL LVDNWEELAK LITIENGKSY NEAYGEVLRG IECVEFAAGA 

       130        140        150        160        170        180 
PTLMMGKQLP DIATGIESGM YRYPIGVIGG ITPFNFPMMV PCWMFPLAIA CGNTFVLKPS 

       190        200        210        220        230        240 
ERTPLLAARL AELAEEAGLP KGVLNIVNGA HDVVNGLLEH KLVKAISFVG SQPVAEYVYK 

       250        260        270        280        290        300 
KGTENLKRVQ ALAGAKNHSI VLNDANLELA TKQIISAAFG SAGERCMAAS VVTVEEEIAD 

       310        320        330        340        350        360 
QLVERLVAEA NKIVIGNGLD EDVFLGPVIR DNHKERTIGY IDSGVEQGAT LVRDGREDTA 

       370        380        390        400        410        420 
VKGAGYFVGP TIFDHVTKEM KIWQDEIFAP VLSIVRVKSL DEAIEIANES RFANGACIYT 

       430        440        450        460        470        480 
DSGASVRQFR ETIESGMLGV NVGVPAPMAF FPFSGWKDSF YGDLHANGTD GVEFYTRKKM 


LTSRWEK

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References

[1]"Genome sequence of Bacillus cereus AH820."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: AH820 EMBL ACK90845.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001283 Genomic DNA. Translation: ACK90845.1.
RefSeqYP_002451479.1. NC_011773.1.

3D structure databases

ProteinModelPortalB7JPM2.
SMRB7JPM2. Positions 9-485.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7JPM2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000086186; EBBACP00000081143; EBBACG00000086179.
GeneID7192015.
GenomeReviewsGene locus BCAH820_2529 in contig CP001283_GR.
KEGGbcu:BCAH820_2529.
PATRIC18841950. VBIBacCer122868_2484.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00070000031871.
HOGENOMHBG752218.
OMAYAEGTRR.
ProtClustDBCLSK2485196.

Family and domain databases

HAMAPMF_01670. IolA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00140.
PANTHERPTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB7JPM2_BACC0
AccessionPrimary (citable) accession number: B7JPM2
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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