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B7JK00 (MURD_BACC0) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:BCAH820_3927
OrganismBacillus cereus (strain AH820) [Complete proteome] [HAMAP]
Taxonomic identifier405535 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_1000130824

Regions

Nucleotide binding119 – 1257ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B7JK00 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: AD0D7A2AB3121646

FASTA45048,901
        10         20         30         40         50         60 
MKTVTEFQNK NILVLGIAKS GYAAATLLQK LGANVIVNDG KPLAENVLAA ELQAKGMDVV 

        70         80         90        100        110        120 
CGGHPLELLE RNISLVVKNP GIPYSNPILV AAKEKQIPIV TEVELAYRIS EAPFVGITGS 

       130        140        150        160        170        180 
NGKTTTTMLT FEMLKEGQKH PVIAGNIGTV ACEVAQDAKE NEVVVTELSS FQLMGVELFQ 

       190        200        210        220        230        240 
PKIAAFLNLF EAHLDYHGTK KEYGLAKANI FKNQTENDYS VINADDADVM ALSAYSKGQK 

       250        260        270        280        290        300 
VLFSTTKEIE DGACIKDNAL YFKAEKVVEV DDIVLPGQHN LENILAAMSI AKLLGVSNEA 

       310        320        330        340        350        360 
ITAVLKRFTG VKHRLEYVTT INNRKFYNDS KATNMLATEK ALSAFTQPTV LLAGGLDRGN 

       370        380        390        400        410        420 
EFDDLIPYFK NVKAIVTFGQ TAPKLVRAAE KAGLDTIESV DTLDEAVVKA YAHSTDGDVI 

       430        440        450 
LLSPACASWD QFKTFEERGD IFIQAVHKLI

« Hide

References

[1]"Genome sequence of Bacillus cereus AH820."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AH820.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001283 Genomic DNA. Translation: ACK89886.1.
RefSeqYP_002452877.1. NC_011773.1.

3D structure databases

ProteinModelPortalB7JK00.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7JK00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000087825; EBBACP00000080974; EBBACG00000087818.
GeneID7188837.
GenomeReviewsGene locus BCAH820_3927 in contig CP001283_GR.
KEGGbcu:BCAH820_3927.
PATRIC18844817. VBIBacCer122868_3917.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00070000032130.
HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBPRK02472.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_BACC0
AccessionPrimary (citable) accession number: B7JK00
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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