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B7JFQ8

- PHNX_BACC0

UniProt

B7JFQ8 - PHNX_BACC0

Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Bacillus cereus (strain AH820)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Involved in phosphonate degradation.UniRule annotation

    Catalytic activityi

    Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei9 – 91NucleophileUniRule annotation
    Metal bindingi9 – 91MagnesiumUniRule annotation
    Metal bindingi11 – 111Magnesium; via carbonyl oxygenUniRule annotation
    Active sitei50 – 501Schiff-base intermediate with substrateUniRule annotation
    Metal bindingi183 – 1831MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. organic phosphonate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Schiff base

    Enzyme and pathway databases

    BioCyciBCER405535:GHSL-1425-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
    Short name:
    PhosphonataseUniRule annotation
    Alternative name(s):
    Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
    Gene namesi
    Name:phnXUniRule annotation
    Ordered Locus Names:BCAH820_1414
    OrganismiBacillus cereus (strain AH820)
    Taxonomic identifieri405535 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000001363: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Phosphonoacetaldehyde hydrolasePRO_1000144826Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405535.BCAH820_1414.

    Structurei

    3D structure databases

    ProteinModelPortaliB7JFQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0637.
    HOGENOMiHOG000217971.
    KOiK05306.
    OMAiGATWEEY.
    OrthoDBiEOG6ZH2FH.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPiMF_01375. PhnX.
    InterProiIPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
    TIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01422. phosphonatase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7JFQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIEAVIFDW AGTTVDYGCF APLEVFMEIF HKRGVGITAE EARKPMGLLK    50
    IDHVRALTEM PRIANEWNRI FGQLPTETDI QEMYEEFEEI LFAILPRYAS 100
    PIHGVKEVIA SLRERGIKIG STTGYTREMM DIVAKEAALQ GYKPDFLVTP 150
    DDVPAGRPYP WMCYKNAMEL GVYPMNHMIK IGDTVSDMKE GRNAGMWTVG 200
    VILGSSELGL SEEEVENMDS AELREKIEVV RNRFVENGAH FTIETMQELE 250
    SVMERIEKQE LIIS 264
    Length:264
    Mass (Da):30,032
    Last modified:February 10, 2009 - v1
    Checksum:iDE04AD84BE0E9033
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001283 Genomic DNA. Translation: ACK88943.1.
    RefSeqiYP_002450365.1. NC_011773.1.

    Genome annotation databases

    EnsemblBacteriaiACK88943; ACK88943; BCAH820_1414.
    GeneIDi7189447.
    KEGGibcu:BCAH820_1414.
    PATRICi18839684. VBIBacCer122868_1355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001283 Genomic DNA. Translation: ACK88943.1 .
    RefSeqi YP_002450365.1. NC_011773.1.

    3D structure databases

    ProteinModelPortali B7JFQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405535.BCAH820_1414.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK88943 ; ACK88943 ; BCAH820_1414 .
    GeneIDi 7189447.
    KEGGi bcu:BCAH820_1414.
    PATRICi 18839684. VBIBacCer122868_1355.

    Phylogenomic databases

    eggNOGi COG0637.
    HOGENOMi HOG000217971.
    KOi K05306.
    OMAi GATWEEY.
    OrthoDBi EOG6ZH2FH.

    Enzyme and pathway databases

    BioCyci BCER405535:GHSL-1425-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPi MF_01375. PhnX.
    InterProi IPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01549. HAD-SF-IA-v1. 1 hit.
    TIGR01509. HAD-SF-IA-v3. 1 hit.
    TIGR01422. phosphonatase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus AH820."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AH820.

    Entry informationi

    Entry nameiPHNX_BACC0
    AccessioniPrimary (citable) accession number: B7JFQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3