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Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Bacillus cereus (strain AH820)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileUniRule annotation
Metal bindingi9 – 91MagnesiumUniRule annotation
Metal bindingi11 – 111Magnesium; via carbonyl oxygenUniRule annotation
Active sitei50 – 501Schiff-base intermediate with substrateUniRule annotation
Metal bindingi183 – 1831MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Schiff base

Enzyme and pathway databases

BioCyciBCER405535:GHSL-1425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
Short name:
PhosphonataseUniRule annotation
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
Gene namesi
Name:phnXUniRule annotation
Ordered Locus Names:BCAH820_1414
OrganismiBacillus cereus (strain AH820)
Taxonomic identifieri405535 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001363 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Phosphonoacetaldehyde hydrolasePRO_1000144826Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi405535.BCAH820_1414.

Structurei

3D structure databases

ProteinModelPortaliB7JFQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000217971.
KOiK05306.
OMAiFDWAGTM.
OrthoDBiEOG6ZH2FH.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.

Sequencei

Sequence statusi: Complete.

B7JFQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEAVIFDW AGTTVDYGCF APLEVFMEIF HKRGVGITAE EARKPMGLLK
60 70 80 90 100
IDHVRALTEM PRIANEWNRI FGQLPTETDI QEMYEEFEEI LFAILPRYAS
110 120 130 140 150
PIHGVKEVIA SLRERGIKIG STTGYTREMM DIVAKEAALQ GYKPDFLVTP
160 170 180 190 200
DDVPAGRPYP WMCYKNAMEL GVYPMNHMIK IGDTVSDMKE GRNAGMWTVG
210 220 230 240 250
VILGSSELGL SEEEVENMDS AELREKIEVV RNRFVENGAH FTIETMQELE
260
SVMERIEKQE LIIS
Length:264
Mass (Da):30,032
Last modified:February 10, 2009 - v1
Checksum:iDE04AD84BE0E9033
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001283 Genomic DNA. Translation: ACK88943.1.
RefSeqiWP_000687376.1. NC_011773.1.
YP_002450365.1. NC_011773.1.

Genome annotation databases

EnsemblBacteriaiACK88943; ACK88943; BCAH820_1414.
KEGGibcu:BCAH820_1414.
PATRICi18839684. VBIBacCer122868_1355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001283 Genomic DNA. Translation: ACK88943.1.
RefSeqiWP_000687376.1. NC_011773.1.
YP_002450365.1. NC_011773.1.

3D structure databases

ProteinModelPortaliB7JFQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405535.BCAH820_1414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK88943; ACK88943; BCAH820_1414.
KEGGibcu:BCAH820_1414.
PATRICi18839684. VBIBacCer122868_1355.

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000217971.
KOiK05306.
OMAiFDWAGTM.
OrthoDBiEOG6ZH2FH.

Enzyme and pathway databases

BioCyciBCER405535:GHSL-1425-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus cereus AH820."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AH820.

Entry informationi

Entry nameiPHNX_BACC0
AccessioniPrimary (citable) accession number: B7JFQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.