Reviewed, UniProtKB/Swiss-Prot B7JES8 (TRPC_BACC0)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BCAH820_1319

Organism

Bacillus cereus (strain AH820) [Complete proteome] [HAMAP]

Taxonomic identifier

405535 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000117768

Sequences

	Sequence		Length	Mass (Da)
	B7JES8-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 764D98A185338466	FASTA	253	28,437
	10 20 30 40 50 60 MGTILDKIVN QKKKEVAALY ETYTPVKEKR KTRSLVKALE QFTVIAEVKR ASPSKGDINL 70 80 90 100 110 120 HVDVRKQVKT YEECGAGAVS VLTDGQFFKG SFYDLQTARE ESSIPLLCKD FIIDKIQIDR 130 140 150 160 170 180 AYEAGADIIL LIVAALTKEK LKELYSYVLE KGLEAIVEVH DEQELEIAIQ LNPHVIGINN 190 200 210 220 230 240 RNLKTFEVDL SQTEKLGKRL NEEKLLWISE SGIHSKEDII RVKRAGAKGV LVGEALMTSS 250 SIHTFFEDCK VNI

References

[1]	"Genome sequence of Bacillus cereus AH820." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001283 Genomic DNA. Translation: ACK89978.1.
RefSeq	YP_002450271.1.
3D structure databases
SMR	B7JES8. Positions 1-247.
ModBase	Search...
Genome annotation databases
GeneID	7191954.
GenomeReviews	Gene locus BCAH820_1319 in contig CP001283_GR.
KEGG	bcu:BCAH820_1319.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACC0

Accession

Primary (citable) accession number: B7JES8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	February 9, 2010
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)