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B7JDC3

- PCP_BACC0

UniProt

B7JDC3 - PCP_BACC0

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, BCAH820_3096
Organism
Bacillus cereus (strain AH820)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801 By similarity
Active sitei143 – 1431 By similarity
Active sitei167 – 1671 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciBCER405535:GHSL-3109-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name:
PGP-I
Short name:
Pyrase
Gene namesi
Name:pcp
Ordered Locus Names:BCAH820_3096
OrganismiBacillus cereus (strain AH820)
Taxonomic identifieri405535 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000001363: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Pyrrolidone-carboxylate peptidaseUniRule annotation
PRO_1000123986Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405535.BCAH820_3096.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C15 family.

Phylogenomic databases

eggNOGiCOG2039.
HOGENOMiHOG000242641.
KOiK01304.
OMAiAKQLPCV.
OrthoDBiEOG6X1124.

Family and domain databases

Gene3Di3.40.630.20. 1 hit.
HAMAPiMF_00417. Pyrrolid_peptidase.
InterProiIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERiPTHR23402. PTHR23402. 1 hit.
PfamiPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSiPR00706. PYROGLUPTASE.
PROSITEiPS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7JDC3-1 [UniParc]FASTAAdd to Basket

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MKTVLLTGFD PFGGESINPA WEVAKSLHEK TIGEYKIISK QVPTVFHKSI    50
SVLKEYIEEL APECIICIGQ AGGRPDITIE RVAINIDDAR IADNEGNQPV 100
DVPVVEEGPA AYWSTLPMKA IVKKLQEEGI PASVSQTAGT FVCNHLFYGL 150
MHELEKHDTK MKGGFIHIPF LPEQASNYPG QPSMSLSTIR KGIELAVEVT 200
TTVEVDIVEI GGATH 215
Length:215
Mass (Da):23,453
Last modified:February 10, 2009 - v1
Checksum:iB2040BEEE870D7F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001283 Genomic DNA. Translation: ACK87438.1.
RefSeqiYP_002452046.1. NC_011773.1.

Genome annotation databases

EnsemblBacteriaiACK87438; ACK87438; BCAH820_3096.
GeneIDi7189132.
KEGGibcu:BCAH820_3096.
PATRICi18843116. VBIBacCer122868_3067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001283 Genomic DNA. Translation: ACK87438.1 .
RefSeqi YP_002452046.1. NC_011773.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405535.BCAH820_3096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK87438 ; ACK87438 ; BCAH820_3096 .
GeneIDi 7189132.
KEGGi bcu:BCAH820_3096.
PATRICi 18843116. VBIBacCer122868_3067.

Phylogenomic databases

eggNOGi COG2039.
HOGENOMi HOG000242641.
KOi K01304.
OMAi AKQLPCV.
OrthoDBi EOG6X1124.

Enzyme and pathway databases

BioCyci BCER405535:GHSL-3109-MONOMER.

Family and domain databases

Gene3Di 3.40.630.20. 1 hit.
HAMAPi MF_00417. Pyrrolid_peptidase.
InterProi IPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view ]
PANTHERi PTHR23402. PTHR23402. 1 hit.
Pfami PF01470. Peptidase_C15. 1 hit.
[Graphical view ]
PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSi PR00706. PYROGLUPTASE.
PROSITEi PS01334. PYRASE_CYS. 1 hit.
PS01333. PYRASE_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus AH820."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AH820.

Entry informationi

Entry nameiPCP_BACC0
AccessioniPrimary (citable) accession number: B7JDC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi