B7JC67 (AROC_ACIF2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	AFE_1972

Organism

Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / NCIB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)) [Complete proteome] [HAMAP]

Taxonomic identifier

243159 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Chorismate synthase HAMAP MF_00300		PRO_1000119484

Sequences

	Sequence		Length	Mass (Da)
	B7JC67 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: A8049DA2B3E73F01	FASTA	363	38,913
	10 20 30 40 50 60 MAGSSIGECF RVSTFGESHG PAIGCIVDGC PPGMTLSAAD IQTELDRRRP GRSRHTTQRQ 70 80 90 100 110 120 EADQVEILSG VFEGLTTGTP IGLLIRNTDQ RSQDYSKIKD LFRPGHADYT YLQKYGLRDY 130 140 150 160 170 180 RGGGRSSARE TAMRVAAGAI ARKFLRERLG VNIQAWMAQM GPIHAEDFDA AEISHNDFFC 190 200 210 220 230 240 PDAGAAIRMA DFLDGLRKEG DSIGARVDAR VSGMPVGLGE PVFDRLEADI AKAMMSINAV 250 260 270 280 290 300 KAIAVGDGFA VVEQRGSYHG DAMAATGFQS NHAGGVLGGI SSGQDLTLSV AIKPTSSIRI 310 320 330 340 350 360 PRQSIDVHGR PAEVITTGRH DPCVGIRAVP IVEAMLALVI MDHWMRHRAQ NADVQAPLPP IPA

References

[1]

"Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications." Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II, Eisen J.A., Holmes D.S. BMC Genomics 9:597-597(2008) [PubMed: 19077236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23270 / DSM 14882 / NCIB 8455.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001219 Genomic DNA. Translation: ACK79724.1.
RefSeq	YP_002426379.1. NC_011761.1.
3D structure databases
ProteinModelPortal	B7JC67.
ModBase	Search...
Protein-protein interaction databases
STRING	B7JC67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7137075.
GenomeReviews	Gene locus AFE_1972 in contig CP001219_GR.
KEGG	afr:AFE_1972.
PATRIC	20655077. VBIAciFer29821_1805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACIF2

Accession

Primary (citable) accession number: B7JC67

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program