B7JBC0 (TRPC_ACIF2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	AFE_3242

Organism

Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / NCIB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)) [Complete proteome] [HAMAP]

Taxonomic identifier

243159 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000117767

Sequences

	Sequence		Length	Mass (Da)
	B7JBC0 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: D56A423203F74555	FASTA	263	28,695
	10 20 30 40 50 60 MTDILQEIIA HKREELVERQ TRLGLAELQA AVALTAPPRN FVGAVRARMA QGQPAVIAEI 70 80 90 100 110 120 KKASPSAGVI REDFNPVTIA QDYAAHGAAC LSVLTDEHYF QGADLYLAAA REACPLPVLR 130 140 150 160 170 180 KDFCIDPYQV WEARAIGADA ILLIVAALSD AELQSLEATA QSLDLAVLVE VHDAAELQRA 190 200 210 220 230 240 LKLRTPLIGI NNRDLRRFVT EIETTLKLLP EIPRERIVVT ESGIRSREEV ATLRAAGVGA 250 260 FLVGEAFMRT AQPGDALQHL FFD

References

[1]

"Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications." Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II, Eisen J.A., Holmes D.S. BMC Genomics 9:597-597(2008) [PubMed: 19077236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23270 / DSM 14882 / NCIB 8455.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001219 Genomic DNA. Translation: ACK80131.1.
RefSeq	YP_002427595.1. NC_011761.1.
3D structure databases
ProteinModelPortal	B7JBC0.
ModBase	Search...
Protein-protein interaction databases
STRING	B7JBC0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7135981.
GenomeReviews	Gene locus AFE_3242 in contig CP001219_GR.
KEGG	afr:AFE_3242.
PATRIC	20657413. VBIAciFer29821_2949.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
ProtClustDB	CLSK2408738.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ACIF2

Accession

Primary (citable) accession number: B7JBC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program