Reviewed, UniProtKB/Swiss-Prot B7J7X4 (DCD_ACIF2)

Names and origin

Protein names

Recommended name:
    Deoxycytidine triphosphate deaminase
      Short name=dCTP deaminase
    EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	AFE_2660

Organism

Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / NCIB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)) [Complete proteome] [HAMAP]

Taxonomic identifier

243159 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_1000189820

Sequences

	Sequence		Length	Mass (Da)
	B7J7X4-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: FE83FC59E602F553	FASTA	188	21,104
	10 20 30 40 50 60 MSIKSDRWIR HMAEEHGMIE PFSPRQVRHV EGNSIISYGL SSYGYDIRCA GEFKVFTNVR 70 80 90 100 110 120 SVIVDPKNFS EHSFVDFTGD TCIIPPNSFA LARTLEYFRI PRNVLTICLG KSTYARCGII 130 140 150 160 170 180 VNVTPFEPEW EGYVTLEFSN TTPLPAKIYA NEGVAQVLFL ESDEVCEVSY ADRGGKYQGQ SGVTLPKA

References

[1]

"Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications." Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II, Eisen J.A., Holmes D.S. BMC Genomics 9:597-597(2008) [PubMed: 19077236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001219 Genomic DNA. Translation: ACK80821.1.
RefSeq	YP_002427037.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7134128.
GenomeReviews	Gene locus AFE_2660 in contig CP001219_GR.
KEGG	afr:AFE_2660.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00146. [Tree]
InterPro	IPR011962. dCTP_deam. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_ACIF2

Accession

Primary (citable) accession number: B7J7X4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	July 28, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)