Reviewed, UniProtKB/Swiss-Prot B7J629 (AROB_ACIF2)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	AFE_0733

Organism

Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / NCIB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)) [Complete proteome] [HAMAP]

Taxonomic identifier

243159 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000117470

Sequences

	Sequence		Length	Mass (Da)
	B7J629-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 9A4FF1B9C0BD2F3B	FASTA	364	38,695
	10 20 30 40 50 60 MRSLCVDLGQ RSYPIHTGTG ILADSALFAP ALSKGPVAVV TDSNVAPLYL ETLQKTLKAL 70 80 90 100 110 120 DKPSLSIILP AGEESKSLDN IQEIAGRLLS AGYGRDCTLC ALGGGVVGDI TGFAAAVYQR 130 140 150 160 170 180 GVAYIQVPTT LLAMVDSSVG GKTGVNHPLG KNMIGAFYQP QAVIADTDTL DSLPEREFRS 190 200 210 220 230 240 GLAEVIKYGL INDQGFFSWL EDHMDAVLAR EPDALTKVIR HSCKDKADIV ARDELEGGLR 250 260 270 280 290 300 AILNLGHTFG HAIEAATGYG QYLHGEAVAI GMVMAADLSR RLDLIRESEQ DRIYALVEAT 310 320 330 340 350 360 GLPTLAPALP VADYLGFMRV DKKAEGGRVR FILLRGIGSA VITGEVPPAA ITQTLQAFME HGHA

References

[1]

"Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications." Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II, Eisen J.A., Holmes D.S. BMC Genomics 9:597-597(2008) [PubMed: 19077236] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001219 Genomic DNA. Translation: ACK78438.1.
RefSeq	YP_002425221.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7134504.
GenomeReviews	Gene locus AFE_0733 in contig CP001219_GR.
KEGG	afr:AFE_0733.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_ACIF2

Accession

Primary (citable) accession number: B7J629

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)