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Reviewed, UniProtKB/Swiss-Prot B7J3V5 (MRAY_ACIF2)

Last modified October 13, 2009. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name: mraY
Ordered Locus Names: AFE_0209
OrganismAcidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / NCIB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)) [Complete proteome] [HAMAP]
Taxonomic identifier243159 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Acidithiobacillales › Acidithiobacillaceae › Acidithiobacillus

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Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000116501

Regions

Transmembrane26 – 4621 Potential
Transmembrane70 – 9021 Potential
Transmembrane94 – 11421 Potential
Transmembrane136 – 15621 Potential
Transmembrane164 – 18421 Potential
Transmembrane199 – 21921 Potential
Transmembrane236 – 25621 Potential
Transmembrane263 – 28321 Potential
Transmembrane289 – 30921 Potential
Transmembrane339 – 35921 Potential

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Sequences

Sequence LengthMass (Da)Tools
B7J3V5-1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 564F7A075673FF43

FASTA36039,009
        10         20         30         40         50         60 
MLYALFMQLG SLYHGFYVFQ YLTLRGVLAT LTALVLSLFI GPFFIARLRR YKIGQMVRND 

        70         80         90        100        110        120 
GPETHLIKQG TPTMGGALIL LVVILTTLLW SDLGNPLVWV AVLTTLAFGA IGFVDDWRKL 

       130        140        150        160        170        180 
RRQNSKGLSA RAKYGLQSLV AFAAGGVLYA LASNPVETSL ILPFIPHVLI PMGAGFIVFS 

       190        200        210        220        230        240 
YFVIVGTSNA VNLTDGLDGL AIVPTVMVAG ALGVFAYVSG NAVFARYLDV PWVPGSGQML 

       250        260        270        280        290        300 
IFCGALVGAG LGFLWFNTYP ADVFMGDTGA LALGAALAIV AIVARQELVL FIMGGVFVVE 

       310        320        330        340        350        360 
TLSVIIQVVS FRLTGKRVFR MAPLHHHFEK KGWPEPRVAV RFWIITVILV LVGLSSLKIR

« Hide

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References

[1]"Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications."
Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II, Eisen J.A., Holmes D.S.
BMC Genomics 9:597-597(2008) [PubMed: 19077236] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP001219 Genomic DNA. Translation: ACK80503.1.
RefSeqYP_002424718.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID7136610.
GenomeReviewsGene locus AFE_0209 in contig CP001219_GR.
KEGGafr:AFE_0209.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_00038.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR018481. Glycosyl_Trfase_4_cons-reg.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameMRAY_ACIF2
AccessionPrimary (citable) accession number: B7J3V5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 13, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents