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B7J2C2

- B7J2C2_BORBZ

UniProt

B7J2C2 - B7J2C2_BORBZ

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Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
gnd, BbuZS7_0571
Organism
Borrelia burgdorferi (strain ZS7)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Substrate By similarity
Active sitei179 – 1791Proton acceptor By similarityUniRule annotation
Active sitei186 – 1861Proton donor By similarityUniRule annotation
Binding sitei187 – 1871Substrate By similarity
Binding sitei255 – 2551Substrate; via amide nitrogen By similarity
Binding sitei282 – 2821Substrate By similarity
Binding sitei440 – 4401Substrate; shared with dimeric partner By similarity
Binding sitei446 – 4461Substrate; shared with dimeric partner By similarityUniRule annotation

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciBBUR445985:GKEU-567-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:gndImported
Ordered Locus Names:BbuZS7_0571Imported
OrganismiBorrelia burgdorferi (strain ZS7)Imported
Taxonomic identifieri445985 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000006901: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi445985.BbuZS7_0571.

Structurei

3D structure databases

ProteinModelPortaliB7J2C2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1263Substrate binding By similarity
Regioni182 – 1832Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.

Sequencei

Sequence statusi: Complete.

B7J2C2-1 [UniParc]FASTAAdd to Basket

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MDVGIYGLGV MGSNLALNIA DNGFNVSVYN RDNEKTEIFV KQNSHKKING    50
FKDVESFVKS LKTPKKIILM VTSSAIEKVI EQILPFMNKS DIIIDGGNSH 100
YKSTMRLEKE LFAKDIYFVG LGISGGERGA RFGPALMYGG SKSAYEILEP 150
MLNKIAAKTK NNDICSTYIG ENGSGHYVKM IHNGVEYADM QLISEVYFFM 200
KKAFNLDNLK ISEVFEKWNE GDLSGYLLEI TSKILKYKEN NEYLVDKILD 250
IANQKGTGVW TAIDALESGV PVNLIVESVF SRFMSGLKHE RIIASDLLKM 300
DTSSFEFELS DWILDLYYAL LVSKIVAYAQ GFMMLKTASV NYGWDLNLGK 350
ISLVWREGCI IRSSFLDKIK LAYDKNPHLI NLLFDDYFLD LLKNNHKSLR 400
RIISKASEIG IPLPAFYASL SFLDSYSTNY LPSNLIQAQR DFFGAHSFER 450
LDSKRGEFFH SAWQ 464
Length:464
Mass (Da):52,543
Last modified:February 10, 2009 - v1
Checksum:i8ACC2A61B2ACCA8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001205 Genomic DNA. Translation: ACK74426.1.
RefSeqiYP_002375067.1. NC_011728.1.

Genome annotation databases

EnsemblBacteriaiACK74426; ACK74426; BbuZS7_0571.
GeneIDi7106500.
KEGGibbz:BbuZS7_0571.
PATRICi20560573. VBIBorBur54821_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001205 Genomic DNA. Translation: ACK74426.1 .
RefSeqi YP_002375067.1. NC_011728.1.

3D structure databases

ProteinModelPortali B7J2C2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 445985.BbuZS7_0571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK74426 ; ACK74426 ; BbuZS7_0571 .
GeneIDi 7106500.
KEGGi bbz:BbuZS7_0571.
PATRICi 20560573. VBIBorBur54821_0692.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci BBUR445985:GKEU-567-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZS7Imported.

Entry informationi

Entry nameiB7J2C2_BORBZ
AccessioniPrimary (citable) accession number: B7J2C2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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