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B7J2C2

- B7J2C2_BORBZ

UniProt

B7J2C2 - B7J2C2_BORBZ

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Borrelia burgdorferi (strain ZS7)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei98 – 981Substrate
    Active sitei179 – 1791Proton acceptorUniRule annotation
    Active sitei186 – 1861Proton donorUniRule annotation
    Binding sitei187 – 1871Substrate
    Binding sitei255 – 2551Substrate; via amide nitrogen
    Binding sitei282 – 2821Substrate
    Binding sitei440 – 4401Substrate; shared with dimeric partner
    Binding sitei446 – 4461Substrate; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBBUR445985:GKEU-567-MONOMER.
    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
    Gene namesi
    Name:gndImported
    Ordered Locus Names:BbuZS7_0571Imported
    OrganismiBorrelia burgdorferi (strain ZS7)Imported
    Taxonomic identifieri445985 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000006901: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi445985.BbuZS7_0571.

    Structurei

    3D structure databases

    ProteinModelPortaliB7J2C2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni124 – 1263Substrate binding
    Regioni182 – 1832Substrate binding

    Sequence similaritiesi

    Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0362.
    HOGENOMiHOG000255147.
    KOiK00033.
    OMAiDKDGVFH.
    OrthoDBiEOG6MSS4W.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000109. 6PGD. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00873. gnd. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7J2C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVGIYGLGV MGSNLALNIA DNGFNVSVYN RDNEKTEIFV KQNSHKKING    50
    FKDVESFVKS LKTPKKIILM VTSSAIEKVI EQILPFMNKS DIIIDGGNSH 100
    YKSTMRLEKE LFAKDIYFVG LGISGGERGA RFGPALMYGG SKSAYEILEP 150
    MLNKIAAKTK NNDICSTYIG ENGSGHYVKM IHNGVEYADM QLISEVYFFM 200
    KKAFNLDNLK ISEVFEKWNE GDLSGYLLEI TSKILKYKEN NEYLVDKILD 250
    IANQKGTGVW TAIDALESGV PVNLIVESVF SRFMSGLKHE RIIASDLLKM 300
    DTSSFEFELS DWILDLYYAL LVSKIVAYAQ GFMMLKTASV NYGWDLNLGK 350
    ISLVWREGCI IRSSFLDKIK LAYDKNPHLI NLLFDDYFLD LLKNNHKSLR 400
    RIISKASEIG IPLPAFYASL SFLDSYSTNY LPSNLIQAQR DFFGAHSFER 450
    LDSKRGEFFH SAWQ 464
    Length:464
    Mass (Da):52,543
    Last modified:February 10, 2009 - v1
    Checksum:i8ACC2A61B2ACCA8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001205 Genomic DNA. Translation: ACK74426.1.
    RefSeqiYP_002375067.1. NC_011728.1.

    Genome annotation databases

    EnsemblBacteriaiACK74426; ACK74426; BbuZS7_0571.
    GeneIDi7106500.
    KEGGibbz:BbuZS7_0571.
    PATRICi20560573. VBIBorBur54821_0692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001205 Genomic DNA. Translation: ACK74426.1 .
    RefSeqi YP_002375067.1. NC_011728.1.

    3D structure databases

    ProteinModelPortali B7J2C2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 445985.BbuZS7_0571.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK74426 ; ACK74426 ; BbuZS7_0571 .
    GeneIDi 7106500.
    KEGGi bbz:BbuZS7_0571.
    PATRICi 20560573. VBIBorBur54821_0692.

    Phylogenomic databases

    eggNOGi COG0362.
    HOGENOMi HOG000255147.
    KOi K00033.
    OMAi DKDGVFH.
    OrthoDBi EOG6MSS4W.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .
    BioCyci BBUR445985:GKEU-567-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006113. 6PGDH_decarbox.
    IPR006115. 6PGDH_NADP-bd.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000109. 6PGD. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00873. gnd. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ZS7Imported.

    Entry informationi

    Entry nameiB7J2C2_BORBZ
    AccessioniPrimary (citable) accession number: B7J2C2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3