Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7J2C2

- B7J2C2_BORBZ

UniProt

B7J2C2 - B7J2C2_BORBZ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Borrelia burgdorferi (strain ZS7)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei98 – 981Substrate
Active sitei179 – 1791Proton acceptorUniRule annotation
Active sitei186 – 1861Proton donorUniRule annotation
Binding sitei187 – 1871Substrate
Binding sitei255 – 2551Substrate; via amide nitrogen
Binding sitei282 – 2821Substrate
Binding sitei440 – 4401Substrate; shared with dimeric partner
Binding sitei446 – 4461Substrate; shared with dimeric partnerUniRule annotation

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Gluconate utilizationUniRule annotation, Pentose shuntUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciBBUR445985:GKEU-567-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
Name:gndImported
Ordered Locus Names:BbuZS7_0571Imported
OrganismiBorrelia burgdorferi (strain ZS7)Imported
Taxonomic identifieri445985 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000006901: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi445985.BbuZS7_0571.

Structurei

3D structure databases

ProteinModelPortaliB7J2C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni124 – 1263Substrate binding
Regioni182 – 1832Substrate binding

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.

Sequencei

Sequence statusi: Complete.

B7J2C2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVGIYGLGV MGSNLALNIA DNGFNVSVYN RDNEKTEIFV KQNSHKKING
60 70 80 90 100
FKDVESFVKS LKTPKKIILM VTSSAIEKVI EQILPFMNKS DIIIDGGNSH
110 120 130 140 150
YKSTMRLEKE LFAKDIYFVG LGISGGERGA RFGPALMYGG SKSAYEILEP
160 170 180 190 200
MLNKIAAKTK NNDICSTYIG ENGSGHYVKM IHNGVEYADM QLISEVYFFM
210 220 230 240 250
KKAFNLDNLK ISEVFEKWNE GDLSGYLLEI TSKILKYKEN NEYLVDKILD
260 270 280 290 300
IANQKGTGVW TAIDALESGV PVNLIVESVF SRFMSGLKHE RIIASDLLKM
310 320 330 340 350
DTSSFEFELS DWILDLYYAL LVSKIVAYAQ GFMMLKTASV NYGWDLNLGK
360 370 380 390 400
ISLVWREGCI IRSSFLDKIK LAYDKNPHLI NLLFDDYFLD LLKNNHKSLR
410 420 430 440 450
RIISKASEIG IPLPAFYASL SFLDSYSTNY LPSNLIQAQR DFFGAHSFER
460
LDSKRGEFFH SAWQ
Length:464
Mass (Da):52,543
Last modified:February 10, 2009 - v1
Checksum:i8ACC2A61B2ACCA8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001205 Genomic DNA. Translation: ACK74426.1.
RefSeqiYP_002375067.1. NC_011728.1.

Genome annotation databases

EnsemblBacteriaiACK74426; ACK74426; BbuZS7_0571.
GeneIDi7106500.
KEGGibbz:BbuZS7_0571.
PATRICi20560573. VBIBorBur54821_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001205 Genomic DNA. Translation: ACK74426.1 .
RefSeqi YP_002375067.1. NC_011728.1.

3D structure databases

ProteinModelPortali B7J2C2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 445985.BbuZS7_0571.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK74426 ; ACK74426 ; BbuZS7_0571 .
GeneIDi 7106500.
KEGGi bbz:BbuZS7_0571.
PATRICi 20560573. VBIBorBur54821_0692.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci BBUR445985:GKEU-567-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZS7Imported.

Entry informationi

Entry nameiB7J2C2_BORBZ
AccessioniPrimary (citable) accession number: B7J2C2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3