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B7J2C2 (B7J2C2_BORBZ) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Name:gnd EMBL ACK74426.1
Ordered Locus Names:BbuZS7_0571 EMBL ACK74426.1
OrganismBorrelia burgdorferi (strain ZS7) [Complete proteome] [HAMAP] EMBL ACK74426.1
Taxonomic identifier445985 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group ›

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU000485

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region124 – 1263Substrate binding By similarity PIRSR PIRSR000109-2
Region182 – 1832Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1791Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1861Proton donor By similarity PIRSR PIRSR000109-1
Binding site981Substrate By similarity PIRSR PIRSR000109-2
Binding site1871Substrate By similarity PIRSR PIRSR000109-2
Binding site2551Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2821Substrate By similarity PIRSR PIRSR000109-2
Binding site4401Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
B7J2C2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 8ACC2A61B2ACCA8D

FASTA46452,543
        10         20         30         40         50         60 
MDVGIYGLGV MGSNLALNIA DNGFNVSVYN RDNEKTEIFV KQNSHKKING FKDVESFVKS 

        70         80         90        100        110        120 
LKTPKKIILM VTSSAIEKVI EQILPFMNKS DIIIDGGNSH YKSTMRLEKE LFAKDIYFVG 

       130        140        150        160        170        180 
LGISGGERGA RFGPALMYGG SKSAYEILEP MLNKIAAKTK NNDICSTYIG ENGSGHYVKM 

       190        200        210        220        230        240 
IHNGVEYADM QLISEVYFFM KKAFNLDNLK ISEVFEKWNE GDLSGYLLEI TSKILKYKEN 

       250        260        270        280        290        300 
NEYLVDKILD IANQKGTGVW TAIDALESGV PVNLIVESVF SRFMSGLKHE RIIASDLLKM 

       310        320        330        340        350        360 
DTSSFEFELS DWILDLYYAL LVSKIVAYAQ GFMMLKTASV NYGWDLNLGK ISLVWREGCI 

       370        380        390        400        410        420 
IRSSFLDKIK LAYDKNPHLI NLLFDDYFLD LLKNNHKSLR RIISKASEIG IPLPAFYASL 

       430        440        450        460 
SFLDSYSTNY LPSNLIQAQR DFFGAHSFER LDSKRGEFFH SAWQ

« Hide

References

[1]"Whole-genome sequences of thirteen isolates of Borrelia burgdorferi."
Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J.
J. Bacteriol. 193:1018-1020(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ZS7 EMBL ACK74426.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001205 Genomic DNA. Translation: ACK74426.1.
RefSeqYP_002375067.1. NC_011728.1.

3D structure databases

ProteinModelPortalB7J2C2.
ModBaseSearch...

Protein-protein interaction databases

STRING445985.BbuZS7_0571.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK74426; ACK74426; BbuZS7_0571.
GeneID7106500.
KEGGbbz:BbuZS7_0571.
PATRIC20560573. VBIBorBur54821_0692.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0362.
HOGENOMHOG000255147.
KOK00033.
OMAKQQIGVI.
ProtClustDBPRK09287.

Enzyme and pathway databases

BioCycBBUR445985:GKEU-567-MONOMER.
UniPathwayUPA00115; UER00410.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. gnd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB7J2C2_BORBZ
AccessionPrimary (citable) accession number: B7J2C2
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: May 29, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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