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B7J223 (UVRC_BORBZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:BbuZS7_0464
OrganismBorrelia burgdorferi (strain ZS7) [Complete proteome] [HAMAP]
Taxonomic identifier445985 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 603603UvrABC system protein C HAMAP-Rule MF_00203
PRO_1000200573

Regions

Domain17 – 9478GIY-YIG

Sequences

Sequence LengthMass (Da)Tools
B7J223 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: B9EDDDB6B4A63484

FASTA60369,833
        10         20         30         40         50         60 
MKENLTNLFE KVIKLPTTSG CYKMLNENKK ILYIGKAKNL RSRVKSYFLE KNSHKIKILM 

        70         80         90        100        110        120 
KNVKSIEVIT TNSEYEALLL ECNLIKTHKP DYNVKLKDGK GYPMVRITHE KYPRIFKTRK 

       130        140        150        160        170        180 
IINDKSEYFG PFTNVKKLDQ VLDFINKTFK IRKCKKKSNA PCLYYHMGQC LGVCYKENLE 

       190        200        210        220        230        240 
KEYQKELDKA KSILNGNISE ISSQIDIKLK HAIQKEDFET AIKLKEIRNS LIEINQIQIV 

       250        260        270        280        290        300 
TKTNNLNIDY VHVHPGENVN TIIVLKYRNG KLVERDANFD ESICKENELI LQFLIQYYTS 

       310        320        330        340        350        360 
INMIVPDKIH IFLKDIDTKN VEKLINEIKN TKTEIIYKET EEILKIMEMA ISNAELSLRE 

       370        380        390        400        410        420 
YENKSTKALE SLKIVLEMDK LPKIIEGFDI AHLKGQETVA SMVTFKMGMP FKENYRLYKL 

       430        440        450        460        470        480 
NSLLKGEIDD FKAIKEVISR RYSEIINNNL ELPNLILIDG GKGQLNAALS ILKGLKIENK 

       490        500        510        520        530        540 
VKVCSLAKKQ ETIFLTTNKK GINLPQGHPA LRILQNVRDE AHRKANGFNK KRREKITLLY 

       550        560        570        580        590        600 
TKIHGIGEKT AQKILKSIGT YKDILPLSEN EISEKIKVNV QLAKRIKEFA IKENSIKNNN 


QDK 

« Hide

References

[1]"Whole-genome sequences of thirteen isolates of Borrelia burgdorferi."
Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J.
J. Bacteriol. 193:1018-1020(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ZS7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001205 Genomic DNA. Translation: ACK74967.1.
RefSeqYP_002374968.1. NC_011728.1.

3D structure databases

ProteinModelPortalB7J223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445985.BbuZS7_0464.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK74967; ACK74967; BbuZS7_0464.
GeneID7106392.
KEGGbbz:BbuZS7_0464.
PATRIC20560359. VBIBorBur54821_0592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279960.
KOK03703.
OMAQTIASCV.
OrthoDBEOG6K13R9.

Enzyme and pathway databases

BioCycBBUR445985:GKEU-460-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR010994. RuvA_2-like.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
[Graphical view]
SUPFAMSSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_BORBZ
AccessionPrimary (citable) accession number: B7J223
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families