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Protein

UvrABC system protein C

Gene

uvrC

Organism
Borrelia burgdorferi (strain ZS7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciBBUR445985:GKEU-460-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:BbuZS7_0464
OrganismiBorrelia burgdorferi (strain ZS7)
Taxonomic identifieri445985 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000006901: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603UvrABC system protein CPRO_1000200573Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi445985.BbuZS7_0464.

Structurei

3D structure databases

ProteinModelPortaliB7J223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 9478GIY-YIGUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR010994. RuvA_2-like.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7J223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENLTNLFE KVIKLPTTSG CYKMLNENKK ILYIGKAKNL RSRVKSYFLE
60 70 80 90 100
KNSHKIKILM KNVKSIEVIT TNSEYEALLL ECNLIKTHKP DYNVKLKDGK
110 120 130 140 150
GYPMVRITHE KYPRIFKTRK IINDKSEYFG PFTNVKKLDQ VLDFINKTFK
160 170 180 190 200
IRKCKKKSNA PCLYYHMGQC LGVCYKENLE KEYQKELDKA KSILNGNISE
210 220 230 240 250
ISSQIDIKLK HAIQKEDFET AIKLKEIRNS LIEINQIQIV TKTNNLNIDY
260 270 280 290 300
VHVHPGENVN TIIVLKYRNG KLVERDANFD ESICKENELI LQFLIQYYTS
310 320 330 340 350
INMIVPDKIH IFLKDIDTKN VEKLINEIKN TKTEIIYKET EEILKIMEMA
360 370 380 390 400
ISNAELSLRE YENKSTKALE SLKIVLEMDK LPKIIEGFDI AHLKGQETVA
410 420 430 440 450
SMVTFKMGMP FKENYRLYKL NSLLKGEIDD FKAIKEVISR RYSEIINNNL
460 470 480 490 500
ELPNLILIDG GKGQLNAALS ILKGLKIENK VKVCSLAKKQ ETIFLTTNKK
510 520 530 540 550
GINLPQGHPA LRILQNVRDE AHRKANGFNK KRREKITLLY TKIHGIGEKT
560 570 580 590 600
AQKILKSIGT YKDILPLSEN EISEKIKVNV QLAKRIKEFA IKENSIKNNN

QDK
Length:603
Mass (Da):69,833
Last modified:February 10, 2009 - v1
Checksum:iB9EDDDB6B4A63484
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001205 Genomic DNA. Translation: ACK74967.1.
RefSeqiYP_002374968.1. NC_011728.1.

Genome annotation databases

EnsemblBacteriaiACK74967; ACK74967; BbuZS7_0464.
GeneIDi7106392.
KEGGibbz:BbuZS7_0464.
PATRICi20560359. VBIBorBur54821_0592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001205 Genomic DNA. Translation: ACK74967.1.
RefSeqiYP_002374968.1. NC_011728.1.

3D structure databases

ProteinModelPortaliB7J223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi445985.BbuZS7_0464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK74967; ACK74967; BbuZS7_0464.
GeneIDi7106392.
KEGGibbz:BbuZS7_0464.
PATRICi20560359. VBIBorBur54821_0592.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Enzyme and pathway databases

BioCyciBBUR445985:GKEU-460-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR010994. RuvA_2-like.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZS7.

Entry informationi

Entry nameiUVRC_BORBZ
AccessioniPrimary (citable) accession number: B7J223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.