B7J223 (UVRC_BORBZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein C
Short name=Protein UvrC

Alternative name(s):
Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	BbuZS7_0464

Organism

Borrelia burgdorferi (strain ZS7) [Complete proteome] [HAMAP]

Taxonomic identifier

445985 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group › Borrelia burgdorferi

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203
Subunit structure	Interacts with UvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UvrC family. Contains 1 GIY-YIG domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 603	603	UvrABC system protein C HAMAP-Rule MF_00203		PRO_1000200573
Regions
	Domain	17 – 94	78	GIY-YIG

Sequences

	Sequence		Length	Mass (Da)
	B7J223 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: B9EDDDB6B4A63484	FASTA	603	69,833
	10 20 30 40 50 60 MKENLTNLFE KVIKLPTTSG CYKMLNENKK ILYIGKAKNL RSRVKSYFLE KNSHKIKILM 70 80 90 100 110 120 KNVKSIEVIT TNSEYEALLL ECNLIKTHKP DYNVKLKDGK GYPMVRITHE KYPRIFKTRK 130 140 150 160 170 180 IINDKSEYFG PFTNVKKLDQ VLDFINKTFK IRKCKKKSNA PCLYYHMGQC LGVCYKENLE 190 200 210 220 230 240 KEYQKELDKA KSILNGNISE ISSQIDIKLK HAIQKEDFET AIKLKEIRNS LIEINQIQIV 250 260 270 280 290 300 TKTNNLNIDY VHVHPGENVN TIIVLKYRNG KLVERDANFD ESICKENELI LQFLIQYYTS 310 320 330 340 350 360 INMIVPDKIH IFLKDIDTKN VEKLINEIKN TKTEIIYKET EEILKIMEMA ISNAELSLRE 370 380 390 400 410 420 YENKSTKALE SLKIVLEMDK LPKIIEGFDI AHLKGQETVA SMVTFKMGMP FKENYRLYKL 430 440 450 460 470 480 NSLLKGEIDD FKAIKEVISR RYSEIINNNL ELPNLILIDG GKGQLNAALS ILKGLKIENK 490 500 510 520 530 540 VKVCSLAKKQ ETIFLTTNKK GINLPQGHPA LRILQNVRDE AHRKANGFNK KRREKITLLY 550 560 570 580 590 600 TKIHGIGEKT AQKILKSIGT YKDILPLSEN EISEKIKVNV QLAKRIKEFA IKENSIKNNN QDK

References

[1]

"Whole-genome sequences of thirteen isolates of Borrelia burgdorferi." Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J. J. Bacteriol. 193:1018-1020(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ZS7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001205 Genomic DNA. Translation: ACK74967.1.
RefSeq	YP_002374968.1. NC_011728.1.
3D structure databases
ProteinModelPortal	B7J223.
ModBase	Search...
Protein-protein interaction databases
STRING	445985.BbuZS7_0464.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK74967; ACK74967; BbuZS7_0464.
GeneID	7106392.
KEGG	bbz:BbuZS7_0464.
PATRIC	20560359. VBIBorBur54821_0592.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279960.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	PRK14670.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR010994. RuvA_2-like. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_BORBZ

Accession

Primary (citable) accession number: B7J223

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program