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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Borrelia burgdorferi (strain ZS7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:BbuZS7_0309
OrganismiBorrelia burgdorferi (strain ZS7)
Taxonomic identifieri445985 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorreliella
Proteomesi
  • UP000006901 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalAdd BLAST21
Transmembranei62 – 82HelicalAdd BLAST21
Transmembranei85 – 105HelicalAdd BLAST21
Transmembranei130 – 150HelicalAdd BLAST21
Transmembranei158 – 178HelicalAdd BLAST21
Transmembranei190 – 210HelicalAdd BLAST21
Transmembranei230 – 250HelicalAdd BLAST21
Transmembranei254 – 274HelicalAdd BLAST21
Transmembranei279 – 299HelicalAdd BLAST21
Transmembranei328 – 348HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001165071 – 351Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST351

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B7J1N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYLLGLRLL KYITFRMAYA TIFAFLLSLI VGPYIILKLK KLRADQILRE
60 70 80 90 100
DGPKRHLSEK AGIPTMGGIL IFFCVFISLV FWSNILNVYF LIMVFVMLGF
110 120 130 140 150
AFLGFIDDFL KIKKKTSDGL KARFKIYGQI IFSFFSVGIL YYFGGEHVSV
160 170 180 190 200
IYFPFIKSFQ IDLGLFYIPF GMFILISASN SFNLTDGLDG LAIGLSIVIT
210 220 230 240 250
GALIIIAYLT SRADFAAYLH IPNIKGSEEL VIFLGALLGG SFGFLWFNAY
260 270 280 290 300
PAKIMMGDTG SLALGAILGM AALILKSEIL FSILAGVFII ETMSVIIQVL
310 320 330 340 350
VYKKTKKRVF KMAPLHHHFE ELGWSEMQVV IRFWIIGLIF AIIALSTIKI

R
Length:351
Mass (Da):39,480
Last modified:February 10, 2009 - v1
Checksum:iF6FE800C0C6151E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001205 Genomic DNA. Translation: ACK74886.1.
RefSeqiWP_002556902.1. NC_011728.1.

Genome annotation databases

EnsemblBacteriaiACK74886; ACK74886; BbuZS7_0309.
KEGGibbz:BbuZS7_0309.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BORBZ
AccessioniPrimary (citable) accession number: B7J1N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families