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B7J1I6 (UPPP_BORBZ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:BbuZS7_0264
OrganismBorrelia burgdorferi (strain ZS7) [Complete proteome] [HAMAP]
Taxonomic identifier445985 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197350

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane145 – 16521Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane246 – 26621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B7J1I6 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: FD08CAB7EE4CD9C5

FASTA26630,271
        10         20         30         40         50         60 
MTNILSAIIL GIIQGITEFL PISSSGHLLL FRHFINLKLS IIFDIYLHLA TVLVIIIYYR 

        70         80         90        100        110        120 
KRILELFLTF IRFSLRKTVK SDLTNLKLIL LILIITIVTG VVGTFISKYE SMFTLSFVLI 

       130        140        150        160        170        180 
NFIITGILIL MLEFNFLKVD FKGNILLAGI FMGLMQGLGA LPGISRSGIT IFSASVIGFN 

       190        200        210        220        230        240 
RKSAFEISFL SLIPIVFGAI LLKHKEFYDI FMVLNFFEIN LGALVAFVVG IFSINFFFKM 

       250        260 
LNNKKLYYFS IYLFALSIIV CYFVRI 

« Hide

References

[1]"Whole-genome sequences of thirteen isolates of Borrelia burgdorferi."
Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J.
J. Bacteriol. 193:1018-1020(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ZS7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001205 Genomic DNA. Translation: ACK74928.1.
RefSeqYP_002374781.1. NC_011728.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING445985.BbuZS7_0264.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK74928; ACK74928; BbuZS7_0264.
GeneID7106079.
KEGGbbz:BbuZS7_0264.
PATRIC20559967. VBIBorBur54821_0402.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycBBUR445985:GKEU-262-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BORBZ
AccessionPrimary (citable) accession number: B7J1I6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families