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B7J1H9

- SYL_BORBZ

UniProt

B7J1H9 - SYL_BORBZ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia burgdorferi (strain ZS7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei620 – 6201ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBUR445985:GKEU-255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BbuZS7_0257
OrganismiBorrelia burgdorferi (strain ZS7)
Taxonomic identifieri445985 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000006901: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Leucine--tRNA ligasePRO_1000199181Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi445985.BbuZS7_0257.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5512"HIGH" regionAdd
BLAST
Motifi617 – 6215"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7J1H9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKYEFIKIE KKWQEFWDNN KTYKVEEDPS IPKEKRLYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP
110 120 130 140 150
QKSTEENINK FKKQIKALGF AYDWDREIRT HEENYYKWTQ WIFLQLYKKG
160 170 180 190 200
LAYVKEMPVW YCPELGTVLA NEEIIQTSDG PKSERGSYSV EKKYLRQWVL
210 220 230 240 250
KITKYAERLL DDLEELEWPE SVKEMQRNWI GKSTGVEIEF EIEGHSDKIK
260 270 280 290 300
VFTTRPDTIF GITYLVIAPE NKLIEKITKN NFKQNVLKYV KHEELKSDLN
310 320 330 340 350
RTSLEKDKSG VFTGSYAFHP ITNEKIPIWV GSYVLGTYGT GAVMGVPAHD
360 370 380 390 400
ERDFQFAKKY QLKILPVISK SGKNEILEKA FVDDGISINS PNEFNNLKNS
410 420 430 440 450
EVKDKVIKWL TKNKKGKEKV AYKLRDWIFS RQRYWGEPIP ILFDKLGNAI
460 470 480 490 500
PLEENDLPLK LPEIANYKPS GTGESPLSRI KDWVNVKDMG FTRETNTMPQ
510 520 530 540 550
WAGSCWYYLR YLDPKNSKEF ANKKKIEYWM PVDLYIGGAE HTVLHLLYSR
560 570 580 590 600
FWHKVLYDLG YVNTKEPFKK LINQGIITSF SYQKENGVLI PNDQVIEKDN
610 620 630 640 650
KFFDKKDNKE VTQVIAKMSK SLKNVINPDD IIKEFGADSM RIYEMFMGPL
660 670 680 690 700
TDSKPWNTKG IIGVFRFLNK IWNLREKELS KENPPREIIS ELHKVIKKVT
710 720 730 740 750
EDTEKLNFNT AISAMMIFIN ELLKYEKNYL NIFKPFIIIL SPYAPHLAEE
760 770 780 790 800
LWEYIGELPS LFKNSKWPKF DESLIIKDKK EIVLQINGKI KDKILLNKET
810 820 830 840
GEKELKEIAM ENSKIKSNLL NKKIVKIIVI KNKLVNIVIK
Length:840
Mass (Da):98,217
Last modified:February 10, 2009 - v1
Checksum:i521EA46AF0095A3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001205 Genomic DNA. Translation: ACK75155.1.
RefSeqiWP_012597411.1. NC_011728.1.
YP_002374774.1. NC_011728.1.

Genome annotation databases

EnsemblBacteriaiACK75155; ACK75155; BbuZS7_0257.
GeneIDi7106292.
KEGGibbz:BbuZS7_0257.
PATRICi20559953. VBIBorBur54821_0395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001205 Genomic DNA. Translation: ACK75155.1 .
RefSeqi WP_012597411.1. NC_011728.1.
YP_002374774.1. NC_011728.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 445985.BbuZS7_0257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK75155 ; ACK75155 ; BbuZS7_0257 .
GeneIDi 7106292.
KEGGi bbz:BbuZS7_0257.
PATRICi 20559953. VBIBorBur54821_0395.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BBUR445985:GKEU-255-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZS7.

Entry informationi

Entry nameiSYL_BORBZ
AccessioniPrimary (citable) accession number: B7J1H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3