B7J1G9 (GLPK_BORBZ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	BbuZS7_0246

Organism

Borrelia burgdorferi (strain ZS7) [Complete proteome] [HAMAP]

Taxonomic identifier

445985 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Glycerol kinase HAMAP MF_00186		PRO_1000118546
Regions
	Nucleotide binding	409 – 413	5	ATP By similarity
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	15	1	ATP By similarity
	Binding site	81	1	Substrate By similarity
	Binding site	133	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	264	1	ATP By similarity
	Binding site	307	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7J1G9 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: D75701CCED2AC8AF	FASTA	501	55,606
	10 20 30 40 50 60 MKYILSIDQG TTSSRAMVFD KNANIKGFAQ KEFTQIYPQP SWVEHDPTEI WGSQLGVITE 70 80 90 100 110 120 AMANARILPN EIDAIGITNQ RETTVIWEKN TGKPIYNAIV WQDRRTAKIC DQLKKEGKDK 130 140 150 160 170 180 IILEKTGLVL DSYFSGTKIM WILDNVEGAR QRAENGELCF GTIDTWILWN LTQKKEHATD 190 200 210 220 230 240 YSNASRTLLL NIKTLEWDDE LLSILNVPRA ILPELKESST IYGKTDKALF GAEIPIAGIA 250 260 270 280 290 300 GDQFAATFGQ ACLKKGMAKN TYGTGCFLTV NIGKEPIISH DKLLTSIAWG RKKSVTYVLE 310 320 330 340 350 360 GSVFIGGAVI QWLRDGLEFF RKSSDAEALA SSVSDNGGVY FVPAFVGLGA PHWDSYARGT 370 380 390 400 410 420 IIGITRGSTK AHITRAALES IAFQSFDILN TMKKSIPNFE IQELRVDGGA SQNNLLMQFQ 430 440 450 460 470 480 ADLLECKVVR PKITETTALG AAYLAGLATG YWQSAEEIVS LWQVDKIFEP SMPKNQKEKL 490 500 LENWNKAVGK AKSWIQNSHS S

References

[1]

"Whole-genome sequences of thirteen isolates of Borrelia burgdorferi." Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J. J. Bacteriol. 193:1018-1020(2011) [PubMed: 20935092] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ZS7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001205 Genomic DNA. Translation: ACK75210.1.
RefSeq	YP_002374764.1. NC_011728.1.
3D structure databases
ProteinModelPortal	B7J1G9.
SMR	B7J1G9. Positions 2-496.
ModBase	Search...
Protein-protein interaction databases
STRING	B7J1G9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000003314; EBBORP00000003053; EBBORG00000003314.
GeneID	7106127.
GenomeReviews	Gene locus BbuZS7_0246 in contig CP001205_GR.
KEGG	bbz:BbuZS7_0246.
PATRIC	20559931. VBIBorBur54821_0385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000006825.
HOGENOM	HBG511469.
OMA	ASETERY.
ProtClustDB	CLSK507458.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_BORBZ

Accession

Primary (citable) accession number: B7J1G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program