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B7J0Q1

- PNP_BORBZ

UniProt

B7J0Q1 - PNP_BORBZ

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, BbuZS7_0835
Organism
Borrelia burgdorferi (strain ZS7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi486 – 4861Magnesium By similarity
Metal bindingi492 – 4921Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBBUR445985:GKEU-831-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:BbuZS7_0835
OrganismiBorrelia burgdorferi (strain ZS7)
Taxonomic identifieri445985 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000006901: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 722722Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_1000147889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi445985.BbuZS7_0835.

Structurei

3D structure databases

ProteinModelPortaliB7J0Q1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini553 – 61260KH
Add
BLAST
Domaini622 – 71796S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7J0Q1-1 [UniParc]FASTAAdd to Basket

« Hide

MRKILKLKIG RDELVFETGF MAKQANGSVL ATYGGSSVLA TVCCSSNVRE    50
DLDFVPLSVE YNEKYYAAGK IPGGFIKREG KPKDKEILVS RLIDRPMRPL 100
FDKRFGREIQ VIPTTLATDQ LNPPDIVGMN AAFTAVFLSD IPFNGPIAAV 150
RMVYLNGKFI VNPSFEEIHD SDLDIVVAGS LNGITMVEGG ANEVGEDILL 200
SAIDGAHEYI KQICNAQKEF LDIVGKKEKL PLAFEEKIFE FKDELRDFVY 250
ADLKEACFVK GKLNRDKAIT LLRNKSYEYF SSLEKLTDSN ESLFHKAFDD 300
FEKEIVRSSI LNDNIRTDGR TPNEIRDIIS EVDILSRTHG SALFTRGETQ 350
ALAVTTLGTS IDEQIMDDID GDKRLNFMLH YNFPPFSVGE TGRLMTGRRE 400
IGHGHLAQRA LESMVPGKND FPYTIRVVSE VLESNGSSSM ATVCAGSMSL 450
MSAGVPVKGQ VAGIAMGLIS EGDKYVVLSD ILGEEDHLGD MDFKVAGTKN 500
GITGFQMDIK IENVTKDLMR DALEQARIGR IHILSIMNTV ISNSRVGISK 550
YAPKIVQLQI DIDKISLVIG STGKTVKAIT DEFEVKVQIE QNGKIILFGD 600
DDFKMQKAKE RIESIVREPK VGEIYEGTVK KINSFGAFIE LTPAKEGFLS 650
TRLKPRDSKY GSGRFGNSNR YSRFGGGGEN IRGNAGLVRP PKLEEGQRIK 700
VKIIDIDKFG KIDLEIVRDK DY 722
Length:722
Mass (Da):80,063
Last modified:February 10, 2009 - v1
Checksum:i3452673C05BFC00A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001205 Genomic DNA. Translation: ACK74607.1.
RefSeqiWP_002656770.1. NC_011728.1.
YP_002375304.1. NC_011728.1.

Genome annotation databases

EnsemblBacteriaiACK74607; ACK74607; BbuZS7_0835.
GeneIDi7106559.
KEGGibbz:BbuZS7_0835.
PATRICi20561099. VBIBorBur54821_0939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001205 Genomic DNA. Translation: ACK74607.1 .
RefSeqi WP_002656770.1. NC_011728.1.
YP_002375304.1. NC_011728.1.

3D structure databases

ProteinModelPortali B7J0Q1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 445985.BbuZS7_0835.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK74607 ; ACK74607 ; BbuZS7_0835 .
GeneIDi 7106559.
KEGGi bbz:BbuZS7_0835.
PATRICi 20561099. VBIBorBur54821_0939.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BBUR445985:GKEU-831-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ZS7.

Entry informationi

Entry nameiPNP_BORBZ
AccessioniPrimary (citable) accession number: B7J0Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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