pnp

Functionⁱ

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityⁱ

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactorⁱ

Mg²⁺UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	486	MagnesiumUniRule annotation		1
Metal bindingⁱ	492	MagnesiumUniRule annotation		1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-EC
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA catabolic process Source: InterPro
RNA processing Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, RNA-binding, Transferase
Ligand	Magnesium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation) Alternative name(s): Polynucleotide phosphorylaseUniRule annotation Short name: PNPaseUniRule annotation
Gene namesⁱ	Name:pnpUniRule annotation Ordered Locus Names:BbuZS7_0835
Organismⁱ	Borrelia burgdorferi (strain ZS7)
Taxonomic identifierⁱ	445985 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Borreliaceae › Borreliella › Borreliella burgdorferi
Proteomesⁱ	UP000006901 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01595

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000147889	1 – 722	Polyribonucleotide nucleotidyltransferaseAdd BLAST		722

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B7J0Q1.
SMRⁱ	B7J0Q1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	553 – 612	KHUniRule annotationAdd BLAST		60
Domainⁱ	622 – 717	S1 motifUniRule annotationAdd BLAST		96

Sequence similaritiesⁱ

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000218326.
KEGG Orthology (KO) More...KOⁱ	K00962.
OMAⁱ	RYMHNYN.

Family and domain databases

Gene3Dⁱ	3.30.1370.10. 1 hit. 3.30.230.70. 2 hits.
HAMAPⁱ	MF_01595. PNPase. 1 hit.
InterProⁱ	View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain.
PANTHERⁱ	PTHR11252. PTHR11252. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit.
PIRSFⁱ	PIRSF005499. PNPase. 1 hit.
SMARTⁱ	View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit.
SUPFAMⁱ	SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits.
TIGRFAMsⁱ	TIGR03591. polynuc_phos. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B7J0Q1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRKILKLKIG RDELVFETGF MAKQANGSVL ATYGGSSVLA TVCCSSNVRE 
        60         70         80         90        100
DLDFVPLSVE YNEKYYAAGK IPGGFIKREG KPKDKEILVS RLIDRPMRPL 
       110        120        130        140        150
FDKRFGREIQ VIPTTLATDQ LNPPDIVGMN AAFTAVFLSD IPFNGPIAAV 
       160        170        180        190        200
RMVYLNGKFI VNPSFEEIHD SDLDIVVAGS LNGITMVEGG ANEVGEDILL 
       210        220        230        240        250
SAIDGAHEYI KQICNAQKEF LDIVGKKEKL PLAFEEKIFE FKDELRDFVY 
       260        270        280        290        300
ADLKEACFVK GKLNRDKAIT LLRNKSYEYF SSLEKLTDSN ESLFHKAFDD 
       310        320        330        340        350
FEKEIVRSSI LNDNIRTDGR TPNEIRDIIS EVDILSRTHG SALFTRGETQ 
       360        370        380        390        400
ALAVTTLGTS IDEQIMDDID GDKRLNFMLH YNFPPFSVGE TGRLMTGRRE 
       410        420        430        440        450
IGHGHLAQRA LESMVPGKND FPYTIRVVSE VLESNGSSSM ATVCAGSMSL 
       460        470        480        490        500
MSAGVPVKGQ VAGIAMGLIS EGDKYVVLSD ILGEEDHLGD MDFKVAGTKN 
       510        520        530        540        550
GITGFQMDIK IENVTKDLMR DALEQARIGR IHILSIMNTV ISNSRVGISK 
       560        570        580        590        600
YAPKIVQLQI DIDKISLVIG STGKTVKAIT DEFEVKVQIE QNGKIILFGD 
       610        620        630        640        650
DDFKMQKAKE RIESIVREPK VGEIYEGTVK KINSFGAFIE LTPAKEGFLS 
       660        670        680        690        700
TRLKPRDSKY GSGRFGNSNR YSRFGGGGEN IRGNAGLVRP PKLEEGQRIK 
       710        720 
VKIIDIDKFG KIDLEIVRDK DY

Length:722

Mass (Da):80,063

Last modified:February 10, 2009 - v1

Checksum:ⁱ3452673C05BFC00A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001205 Genomic DNA. Translation: ACK74607.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP001205 Genomic DNA. Translation: ACK74607.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACK74607; ACK74607; BbuZS7_0835.
KEGGⁱ	bbz:BbuZS7_0835.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B7J0Q1	A0A0E1U9I4	Borrelia burgdorferi 64b	722	UniRef100_B7J0Q1	Cluster: Polyribonucleotide nucleotidyltransferase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B7J0Q1	Q0SM46 B9X7J1 A0A1G4P246 A0A0E1U9I4 A0A1L8ZAN2 A0A1L8ZAN6 C0AM51 A0A0A7UWH0 A0A1L6VRV6 D6RWF3 +35	Borrelia afzelii (strain PKo) Borreliella spielmanii A14S Borreliella japonica (Borrelia japonica) Borrelia burgdorferi 64b Borreliella bissettii (Borrelia bissettii) Borreliella finlandensis Borreliella chilensis Borrelia mayonii Borreliella valaisiana VS116 Borreliella afzelii (Borrelia afzelii) And more	722	UniRef90_Q0SM46	Cluster: Polyribonucleotide nucleotidyltransferase	46

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B7J0Q1	Q0SM46 B9X7J1 A0A1G4P246 UPI00016B348F C0AM51 D6RWF3 UPI0004E8424F UPI0005C48F3C A0A1L8ZAN6 A0A0A7UWH0 +91	Borrelia afzelii (strain PKo) Borreliella spielmanii A14S Borreliella japonica (Borrelia japonica) Borreliella afzelii (Borrelia afzelii) Borreliella finlandensis Borreliella valaisiana VS116 Borreliella bissettii (Borrelia bissettii) Borreliella chilensis Borrelia burgdorferi 64b Borrelia mayonii And more	722	UniRef50_Q0SM46	Cluster: Polyribonucleotide nucleotidyltransferase	102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001205 Genomic DNA. Translation: ACK74607.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

CP001205 Genomic DNA. Translation: ACK74607.1.

3D structure databases

ProteinModelPortalⁱ	B7J0Q1.
SMRⁱ	B7J0Q1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACK74607; ACK74607; BbuZS7_0835.
KEGGⁱ	bbz:BbuZS7_0835.

Phylogenomic databases

HOGENOMⁱ	HOG000218326.
KEGG Orthology (KO) More...KOⁱ	K00962.
OMAⁱ	RYMHNYN.

Family and domain databases

Gene3Dⁱ	3.30.1370.10. 1 hit. 3.30.230.70. 2 hits.
HAMAPⁱ	MF_01595. PNPase. 1 hit.
InterProⁱ	View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain.
PANTHERⁱ	PTHR11252. PTHR11252. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit.
PIRSFⁱ	PIRSF005499. PNPase. 1 hit.
SMARTⁱ	View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit.
SUPFAMⁱ	SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits.
TIGRFAMsⁱ	TIGR03591. polynuc_phos. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PNP_BORBZ
Accessionⁱ	B7J0Q1Primary (citable) accession number: B7J0Q1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
	Last sequence update:	February 10, 2009
	Last modified:	February 28, 2018
	This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB - B7J0Q1 (PNP_BORBZ)

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Polyribonucleotide nucleotidyltransferase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Cofactorⁱ

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B7J0Q1 (PNP_BORBZ)

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Polyribonucleotide nucleotidyltransferase

pnp

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ