UniProtKB - B7J0Q1 (PNP_BORBZ)
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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp
Organism
Borrelia burgdorferi (strain ZS7)
Status
Functioni
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation
Catalytic activityi
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 486 | MagnesiumUniRule annotation | 1 | |
Metal bindingi | 492 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-EC
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA catabolic process Source: InterPro
- RNA processing Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)Alternative name(s): Polynucleotide phosphorylaseUniRule annotation Short name: PNPaseUniRule annotation |
Gene namesi | Name:pnpUniRule annotation Ordered Locus Names:BbuZS7_0835 |
Organismi | Borrelia burgdorferi (strain ZS7) |
Taxonomic identifieri | 445985 [NCBI] |
Taxonomic lineagei | Bacteria › Spirochaetes › Spirochaetales › Borreliaceae › Borreliella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000147889 | 1 – 722 | Polyribonucleotide nucleotidyltransferaseAdd BLAST | 722 |
Structurei
3D structure databases
ProteinModelPortali | B7J0Q1. |
SMRi | B7J0Q1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 553 – 612 | KHUniRule annotationAdd BLAST | 60 | |
Domaini | 622 – 717 | S1 motifUniRule annotationAdd BLAST | 96 |
Sequence similaritiesi
Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000218326. |
KOi | K00962. |
OMAi | RYMHNYN. |
Family and domain databases
Gene3Di | 3.30.1370.10. 1 hit. 3.30.230.70. 2 hits. |
HAMAPi | MF_01595. PNPase. 1 hit. |
InterProi | View protein in InterPro IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR036345. ExoRNase_PH_dom2_sf. IPR004087. KH_dom. IPR004088. KH_dom_type_1. IPR036612. KH_dom_type_1_sf. IPR012340. NA-bd_OB-fold. IPR012162. PNPase. IPR027408. PNPase/RNase_PH_dom_sf. IPR015848. PNPase_PH_RNA-bd_bac/org-type. IPR020568. Ribosomal_S5_D2-typ_fold. IPR022967. S1_dom. IPR003029. S1_domain. |
PANTHERi | PTHR11252. PTHR11252. 1 hit. |
Pfami | View protein in Pfam PF00013. KH_1. 1 hit. PF03726. PNPase. 1 hit. PF01138. RNase_PH. 2 hits. PF03725. RNase_PH_C. 2 hits. PF00575. S1. 1 hit. |
PIRSFi | PIRSF005499. PNPase. 1 hit. |
SMARTi | View protein in SMART SM00322. KH. 1 hit. SM00316. S1. 1 hit. |
SUPFAMi | SSF50249. SSF50249. 1 hit. SSF54211. SSF54211. 2 hits. SSF54791. SSF54791. 1 hit. SSF55666. SSF55666. 2 hits. |
TIGRFAMsi | TIGR03591. polynuc_phos. 1 hit. |
PROSITEi | View protein in PROSITE PS50084. KH_TYPE_1. 1 hit. PS50126. S1. 1 hit. |
i Sequence
Sequence statusi: Complete.
B7J0Q1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKILKLKIG RDELVFETGF MAKQANGSVL ATYGGSSVLA TVCCSSNVRE
60 70 80 90 100
DLDFVPLSVE YNEKYYAAGK IPGGFIKREG KPKDKEILVS RLIDRPMRPL
110 120 130 140 150
FDKRFGREIQ VIPTTLATDQ LNPPDIVGMN AAFTAVFLSD IPFNGPIAAV
160 170 180 190 200
RMVYLNGKFI VNPSFEEIHD SDLDIVVAGS LNGITMVEGG ANEVGEDILL
210 220 230 240 250
SAIDGAHEYI KQICNAQKEF LDIVGKKEKL PLAFEEKIFE FKDELRDFVY
260 270 280 290 300
ADLKEACFVK GKLNRDKAIT LLRNKSYEYF SSLEKLTDSN ESLFHKAFDD
310 320 330 340 350
FEKEIVRSSI LNDNIRTDGR TPNEIRDIIS EVDILSRTHG SALFTRGETQ
360 370 380 390 400
ALAVTTLGTS IDEQIMDDID GDKRLNFMLH YNFPPFSVGE TGRLMTGRRE
410 420 430 440 450
IGHGHLAQRA LESMVPGKND FPYTIRVVSE VLESNGSSSM ATVCAGSMSL
460 470 480 490 500
MSAGVPVKGQ VAGIAMGLIS EGDKYVVLSD ILGEEDHLGD MDFKVAGTKN
510 520 530 540 550
GITGFQMDIK IENVTKDLMR DALEQARIGR IHILSIMNTV ISNSRVGISK
560 570 580 590 600
YAPKIVQLQI DIDKISLVIG STGKTVKAIT DEFEVKVQIE QNGKIILFGD
610 620 630 640 650
DDFKMQKAKE RIESIVREPK VGEIYEGTVK KINSFGAFIE LTPAKEGFLS
660 670 680 690 700
TRLKPRDSKY GSGRFGNSNR YSRFGGGGEN IRGNAGLVRP PKLEEGQRIK
710 720
VKIIDIDKFG KIDLEIVRDK DY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001205 Genomic DNA. Translation: ACK74607.1. |
Genome annotation databases
EnsemblBacteriai | ACK74607; ACK74607; BbuZS7_0835. |
KEGGi | bbz:BbuZS7_0835. |
Similar proteinsi
Entry informationi
Entry namei | PNP_BORBZ | |
Accessioni | B7J0Q1Primary (citable) accession number: B7J0Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | February 10, 2009 | |
Last modified: | February 28, 2018 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |