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B7J0L2 (MURG_BORBZ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BbuZS7_0795
OrganismBorrelia burgdorferi (strain ZS7) [Complete proteome] [HAMAP]
Taxonomic identifier445985 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_1000116469

Sequences

Sequence LengthMass (Da)Tools
B7J0L2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 1BAFA347384DB235

FASTA36341,118
        10         20         30         40         50         60 
MSNKKIIFFT GGGTGGHVFP GISIIQKLKE FDNEIEFFWI GKKNSIEEKL IKEQDNIKFI 

        70         80         90        100        110        120 
SIPCGKLRRY FSFKNFTDFF KVILGIIKSF YVLKKYKPQL IYATGGFVST PAIIASSLLK 

       130        140        150        160        170        180 
IKSITHEMDL DPGLATKINS KFANNIHISF KESEKYFKNY KNIIYTGSPI RREFLNPDPK 

       190        200        210        220        230        240 
IIKQLTQNTN KPIISILGGS LGANALNNLA LCIKKDAEIY FIHQSGKNLN DLSEKNYLRR 

       250        260        270        280        290        300 
QFFNAEEMAS IVKFSNLIIS RAGAGAIKEF ANAGACAILI PFKKGSRGDQ IKNAKLLTNQ 

       310        320        330        340        350        360 
NACIYIDEDE ILNINILKII KKTLKDREKI NSLKENIKKF NNKHSSTLIA KLLIKDIKET 


KSK

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References

[1]"Whole-genome sequences of thirteen isolates of Borrelia burgdorferi."
Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J., Mongodin E.F., Luft B.J.
J. Bacteriol. 193:1018-1020(2011) [PubMed: 20935092] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ZS7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001205 Genomic DNA. Translation: ACK74993.1.
RefSeqYP_002375265.1. NC_011728.1.

3D structure databases

ProteinModelPortalB7J0L2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7J0L2.

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000003133; EBBORP00000002872; EBBORG00000003133.
GeneID7106220.
GenomeReviewsGene locus BbuZS7_0795 in contig CP001205_GR.
KEGGbbz:BbuZS7_0795.
PATRIC20561019. VBIBorBur54821_0900.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007289.
HOGENOMHBG617076.
OMAHICGKGN.
ProtClustDBPRK00726.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BORBZ
AccessionPrimary (citable) accession number: B7J0L2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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