Reviewed, UniProtKB/Swiss-Prot B7IYI7 (AROE_BACC2)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BCG9842_B0783

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000118869
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	B7IYI7-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 8DC59A1CA37BD49D	FASTA	277	30,152
	10 20 30 40 50 60 MKQLYGVIGN PIGHSLSPVM HNNAFEHLNM DAHYHAFLVE EEVLGEAVRG LKALGISGFN 70 80 90 100 110 120 VTTPHKVAIM EYLDEIDPLA RKIGAVNTVV HKNGRLIGYN TDGIGFVRAL QSISHEPLQG 130 140 150 160 170 180 KRILLLGAGG ASRAIYFSLA DVGVKEIDVA NRTVDKAKEL IAARTADVNS VALSLEKATE 190 200 210 220 230 240 EQGNYDIIIQ TTTIGMHPHV EHTPLQICSL KKGTIVSDII YNPFETKILC EAKEQGAIIQ 250 260 270 NGIDMFVYQG ALAFEMWTGS VPNIGRMKQL VIEKLGG

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001186 Genomic DNA. Translation: ACK95575.1.
RefSeq	YP_002447913.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7182714.
GenomeReviews	Gene locus BCG9842_B0783 in contig CP001186_GR.
KEGG	bcg:BCG9842_B0783.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BACC2

Accession

Primary (citable) accession number: B7IYI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)