B7IWP4 (ARGB_BACC2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	BCG9842_B0996

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC carbamate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000117117
Regions
	Region	40 – 41	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	153	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	212	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7IWP4 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 34DBE8371B1D6539	FASTA	255	27,043
	10 20 30 40 50 60 MSDYIVVKCG GSMLNQLNAV FFDCIKKLQQ KYKVVIIHGG GPEIDAKLKD CNINVEKRDG 70 80 90 100 110 120 LRVTPKEVMD VVQMVLCGST NKKLVMNLQK HNLLAVGCSG CDGNLLQVQP VSEEIGYVGE 130 140 150 160 170 180 VSYVETALLK GLINMGYIPV IAPIGVNGNE IYNINADNAA AGIAAALGAK ELIFITDVDG 190 200 210 220 230 240 ILHEGNLVKE TDESEIATFI ETGVITGGMI PKVQAALASL KMGVQKISIV NGTKDFTEVT 250 GECIGTTVTK GVSIA

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G9842.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001186 Genomic DNA. Translation: ACK94780.1.
RefSeq	YP_002447704.1. NC_011772.1.
3D structure databases
ProteinModelPortal	B7IWP4.
ModBase	Search...
Protein-protein interaction databases
STRING	B7IWP4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000105296; EBBACP00000100306; EBBACG00000105289.
GeneID	7182126.
GenomeReviews	Gene locus BCG9842_B0996 in contig CP001186_GR.
KEGG	bcg:BCG9842_B0996.
PATRIC	18904013. VBIBacCer50903_4158.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000001971.
HOGENOM	HBG497643.
OMA	CNINVEK.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR003964. Bac_carb_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR01469. CARBMTKINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BACC2

Accession

Primary (citable) accession number: B7IWP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program