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B7IUS2 (MURD_BACC2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:BCG9842_B1228
OrganismBacillus cereus (strain G9842) [Complete proteome] [HAMAP]
Taxonomic identifier405531 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_1000130825

Regions

Nucleotide binding119 – 1257ATP Potential

Sequences

Sequence LengthMass (Da)Tools
B7IUS2 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: F55454EC2369164F

FASTA45048,982
        10         20         30         40         50         60 
MKTVTEFQNK NILVLGIAKS GYAAATLLQK LGANVIVNDG KPLADNVLAA ELQAKGMDVV 

        70         80         90        100        110        120 
CGGHPLELLE RNISLVVKNP GIPYSNPILV AAKEKEIPIV TEVELAYRIS KAPFVGITGS 

       130        140        150        160        170        180 
NGKTTTTMLT FEMLKEGQKH PVIAGNIGTV ACEVAQDAKE NEVVVTELSS FQLMGVESFQ 

       190        200        210        220        230        240 
PKIAAFLNLF EAHLDYHGTK KEYGLAKANV FKNQTENDYS VINADDADVM ELSADTKGQK 

       250        260        270        280        290        300 
ILFSTTKEIE DGACIKDNAL YFKGEKVVEV SDIVLPGQHN LENILAAMSI AKLLGTSNEA 

       310        320        330        340        350        360 
ITVVLKRFTG VKHRLEYVTT INNRKFYNDS KATNMLATEK ALSAFTQPIV LLAGGLDRGN 

       370        380        390        400        410        420 
EFDDLIPYFK NVKAIVTFGQ TAPKLVRAAE KAGLDIIESV DTLDEAVVKA YAHSKEDDVV 

       430        440        450 
LLSPACASWD QFKTFEERGD IFIQAVHKLI

« Hide

References

[1]"Genome sequence of Bacillus cereus G9842."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G9842.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001186 Genomic DNA. Translation: ACK97508.1.
RefSeqYP_002447477.1. NC_011772.1.

3D structure databases

ProteinModelPortalB7IUS2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7IUS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000102846; EBBACP00000099145; EBBACG00000102839.
GeneID7184051.
GenomeReviewsGene locus BCG9842_B1228 in contig CP001186_GR.
KEGGbcg:BCG9842_B1228.
PATRIC18903554. VBIBacCer50903_3929.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00070000032130.
HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBPRK02472.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_BACC2
AccessionPrimary (citable) accession number: B7IUS2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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