Reviewed, UniProtKB/Swiss-Prot B7IUP9 (PYRB_BACC2)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BCG9842_B1254

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000191902

Sequences

	Sequence		Length	Mass (Da)
	B7IUP9-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 614BB702E42CFA13	FASTA	304	34,675
	10 20 30 40 50 60 MSHLLTMSEL SEVEISEILK DAEDFANGKE SKTTEQTFVA NLFFENSTRT RFSFEVAEKR 70 80 90 100 110 120 LGLDVLNFSA DASSVQKGET LYDTIRTLES IGTKAVIVRH EQDRYFDELK DQVNIPILNA 130 140 150 160 170 180 GDGCGNHPTQ CLLDLLTIKQ EFGRFEGLKI AIVGDVRHSR VARSNAEALT KLGATIYFAS 190 200 210 220 230 240 PEEWKDEDST FGTYKPLDEL VPEVDVMMLL RVQHERHDHY ETDIMKEYHE RHGLTVEREK 250 260 270 280 290 300 RMKEGSIIMH PAPVNRDVEV ASELVECERS RIFKQMENGV YVRMAVLKRA LPNVLGGMKH ELLV

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001186 Genomic DNA. Translation: ACK95388.1.
RefSeq	YP_002447454.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7186218.
GenomeReviews	Gene locus BCG9842_B1254 in contig CP001186_GR.
KEGG	bcg:BCG9842_B1254.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACC2

Accession

Primary (citable) accession number: B7IUP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)