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Reviewed, UniProtKB/Swiss-Prot B7IUP2 (PYRE_BACC2)

Last modified February 9, 2010. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Orotate phosphoribosyltransferase
      Short name=OPRT
      Short name=OPRTase
    EC=2.4.2.10
Gene names
Name: pyrE
Ordered Locus Names: BCG9842_B1261
OrganismBacillus cereus (strain G9842) [Complete proteome] [HAMAP]
Taxonomic identifier405531 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

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Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_1000138761

Regions

Region120 – 12895-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site9415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site9815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1241Orotate By similarity

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Sequences

Sequence LengthMass (Da)Tools
B7IUP2-1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: FBE60B786C853B4B

FASTA21022,718
        10         20         30         40         50         60 
MKKEIASHLL EIGAVFLQPN DPFTWSSGMK SPIYCDNRLT LSYPKVRQAI AAGLEELIKE 

        70         80         90        100        110        120 
HFPTVEVIAG TATAGIAHAA WVSDRMDLPM CYVRSKAKGH GKGNQIEGKA EKGQKVVVVE 

       130        140        150        160        170        180 
DLISTGGSAI TCVEALREAG CEVLGIVSIF TYELESGKEK LEAANVASYS LSDYSALTEV 

       190        200        210 
AAEKGMIGQA ETKKLQEWRK NPADEAWITA

« Hide

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References

[1]"Genome sequence of Bacillus cereus G9842."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001186 Genomic DNA. Translation: ACK94229.1.
RefSeqYP_002447447.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID7183928.
GenomeReviewsGene locus BCG9842_B1261 in contig CP001186_GR.
KEGGbcg:BCG9842_B1261.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMAPMCYVRS.

Family and domain databases

HAMAPMF_01208_B. PyrE_B.
[Tree]
InterProIPR004467. Or_phspho_trans.
IPR000836. PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. pyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePYRE_BACC2
AccessionPrimary (citable) accession number: B7IUP2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: February 9, 2010
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents