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B7IUA4

- FTHS_BACC2

UniProt

B7IUA4 - FTHS_BACC2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus cereus (strain G9842)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 788ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCER405531:GI5L-2080-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:BCG9842_B3197
    OrganismiBacillus cereus (strain G9842)
    Taxonomic identifieri405531 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000006744: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_1000146673Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405531.BCG9842_B3197.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7IUA4-1 [UniParc]FASTAAdd to Basket

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    MTTTTTVKSD IEIAQEASMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI    50
    FKRLQDEKDG KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR 100
    EPSLGPTMGL KGGAAGGGFS QVVPMEDINL HFTGDIHAIT TANNALAAFI 150
    DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL RNVVIGLGGP VQGVPREDGF 200
    DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT VKDLGVEGAL 250
    TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY 300
    VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ 350
    LKEENVDALA KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVTYLQE 400
    WCNERGYAVS LTEVWEKGGQ GGVDLAEKVL KEIEKGENNY APLYELELPL 450
    EEKIRTIAQK VYGAKDIEFA PKARKQLAQY EGEGWSNLPV CMAKTQYSLS 500
    DDATKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG LPKQPAALQM 550
    DVNEDGKAVG LF 562
    Length:562
    Mass (Da):60,479
    Last modified:February 10, 2009 - v1
    Checksum:i973BABF0A87462CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001186 Genomic DNA. Translation: ACK93851.1.
    RefSeqiYP_002445524.1. NC_011772.1.

    Genome annotation databases

    EnsemblBacteriaiACK93851; ACK93851; BCG9842_B3197.
    GeneIDi7182325.
    KEGGibcg:BCG9842_B3197.
    PATRICi18899658. VBIBacCer50903_1984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001186 Genomic DNA. Translation: ACK93851.1 .
    RefSeqi YP_002445524.1. NC_011772.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405531.BCG9842_B3197.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK93851 ; ACK93851 ; BCG9842_B3197 .
    GeneIDi 7182325.
    KEGGi bcg:BCG9842_B3197.
    PATRICi 18899658. VBIBacCer50903_1984.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci BCER405531:GI5L-2080-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus G9842."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G9842.

    Entry informationi

    Entry nameiFTHS_BACC2
    AccessioniPrimary (citable) accession number: B7IUA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3