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B7IUA4

- FTHS_BACC2

UniProt

B7IUA4 - FTHS_BACC2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Bacillus cereus (strain G9842)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER405531:GI5L-2080-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BCG9842_B3197
OrganismiBacillus cereus (strain G9842)
Taxonomic identifieri405531 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000006744: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Formate--tetrahydrofolate ligasePRO_1000146673Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405531.BCG9842_B3197.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7IUA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTTTTVKSD IEIAQEASMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI
60 70 80 90 100
FKRLQDEKDG KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR
110 120 130 140 150
EPSLGPTMGL KGGAAGGGFS QVVPMEDINL HFTGDIHAIT TANNALAAFI
160 170 180 190 200
DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL RNVVIGLGGP VQGVPREDGF
210 220 230 240 250
DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT VKDLGVEGAL
260 270 280 290 300
TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY
310 320 330 340 350
VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ
360 370 380 390 400
LKEENVDALA KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVTYLQE
410 420 430 440 450
WCNERGYAVS LTEVWEKGGQ GGVDLAEKVL KEIEKGENNY APLYELELPL
460 470 480 490 500
EEKIRTIAQK VYGAKDIEFA PKARKQLAQY EGEGWSNLPV CMAKTQYSLS
510 520 530 540 550
DDATKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG LPKQPAALQM
560
DVNEDGKAVG LF
Length:562
Mass (Da):60,479
Last modified:February 10, 2009 - v1
Checksum:i973BABF0A87462CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001186 Genomic DNA. Translation: ACK93851.1.
RefSeqiYP_002445524.1. NC_011772.1.

Genome annotation databases

EnsemblBacteriaiACK93851; ACK93851; BCG9842_B3197.
GeneIDi7182325.
KEGGibcg:BCG9842_B3197.
PATRICi18899658. VBIBacCer50903_1984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001186 Genomic DNA. Translation: ACK93851.1 .
RefSeqi YP_002445524.1. NC_011772.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405531.BCG9842_B3197.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK93851 ; ACK93851 ; BCG9842_B3197 .
GeneIDi 7182325.
KEGGi bcg:BCG9842_B3197.
PATRICi 18899658. VBIBacCer50903_1984.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci BCER405531:GI5L-2080-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus G9842."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G9842.

Entry informationi

Entry nameiFTHS_BACC2
AccessioniPrimary (citable) accession number: B7IUA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 1, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3