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Protein

Aconitate hydratase

Gene

acnA

Organism
Bacillus cereus (strain G9842)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.UniRule annotation

Catalytic activityi

Citrate = isocitrate.UniRule annotation

Cofactori

Note: Binds 1 [4Fe-4S] cluster per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBCER405531:GI5L-3674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aconitate hydrataseUniRule annotation (EC:4.2.1.3UniRule annotation)
Short name:
AconitaseUniRule annotation
Gene namesi
Name:acnAImported
Ordered Locus Names:BCG9842_B1593Imported
OrganismiBacillus cereus (strain G9842)Imported
Taxonomic identifieri405531 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000006744 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1048.
HOGENOMiHOG000025703.
KOiK01681.
OMAiDREIQYR.
OrthoDBiEOG67DPHM.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015934. Aconitase/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ISF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKHNPFQSR ATFEVDGKTY HYYDLKALEN AGVGNVSQLP YSVKVLLESV
60 70 80 90 100
LRQVDGRVIT EEHVTNLAKW GTKDVQDIDV PFKPSRVILQ DFTGVPAVVD
110 120 130 140 150
LASLRKAMAD MGGDPDKINP EITVDLVIDH SVQVDRAGTA DALAFNMDLE
160 170 180 190 200
FKRNEERYKF LSWAQKSFDN YRAVPPATGI VHQVNLEYLA PVVHAVKNAE
210 220 230 240 250
GDLVAYPDSL VGTDSHTTMI NGIGVLGWGV GGIEAEAGML GQPSYFPVPE
260 270 280 290 300
VIGVKLTGTL PSGTTATDVA LKVTQVLRQK GVVGKFVEFF GNGLKSMPLA
310 320 330 340 350
DRATISNMAP EYGATCGFFP IDDISLEYLR LTGRDEEQIR IVEEYCKANG
360 370 380 390 400
LFYTADSKDP IYTDLVEIDL NTIESNLSGP KRPQDLIPLS DMKDAFHKAV
410 420 430 440 450
LAPVGTQGLG FNEQEFDKEV KVTLEDKEVT MKTGAIAIAA ITSCTNTSNP
460 470 480 490 500
YVLIGAGLVA KKAIEKGLVV PEYVKTSLAP GSKVVTEYLD KSGLTTYLDQ
510 520 530 540 550
LGFQTVGYGC TTCIGNSGPL APELEESIAA NDLLVTSVLS GNRNFEGRIH
560 570 580 590 600
PLVKANYLAS PPLVVAYALA GTVDIDLKND EIGKDANGNA VYFNDIWPSA
610 620 630 640 650
KEIEDVVQSV VTSELFKKEY AQVFNSNERW NEIQTSNEAL YTWDNDSTYI
660 670 680 690 700
QNPPFFEGLS KEPGEVETLS GLRIVGKFGD SVTTDHISPA GSIGKHTPAG
710 720 730 740 750
RYLLENGVQP VDFNSYGSRR GNHEVMMRGT FANIRIKNQI APGTEGGYTT
760 770 780 790 800
YWPTGEVTSI YDAAMKYKED GTGLLVVAGK DYGMGSSRDW AAKGTNLLGI
810 820 830 840 850
KAVIAESFER IHRSNLVLMG VLPLQFKEGE SAETLGLVGN ESFEIQIDKS
860 870 880 890 900
VRPRDLVKVV ATDLDGNEKQ FEVVARFDSE VEIDYYRHGG ILQMVLREKI

EESKVSN
Length:907
Mass (Da):99,054
Last modified:February 10, 2009 - v1
Checksum:i406D24884514C121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001186 Genomic DNA. Translation: ACK94745.1.
RefSeqiWP_000238553.1. NC_011772.1.

Genome annotation databases

EnsemblBacteriaiACK94745; ACK94745; BCG9842_B1593.
KEGGibcg:BCG9842_B1593.
PATRICi18902835. VBIBacCer50903_3570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001186 Genomic DNA. Translation: ACK94745.1.
RefSeqiWP_000238553.1. NC_011772.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK94745; ACK94745; BCG9842_B1593.
KEGGibcg:BCG9842_B1593.
PATRICi18902835. VBIBacCer50903_3570.

Phylogenomic databases

eggNOGiCOG1048.
HOGENOMiHOG000025703.
KOiK01681.
OMAiDREIQYR.
OrthoDBiEOG67DPHM.

Enzyme and pathway databases

BioCyciBCER405531:GI5L-3674-MONOMER.

Family and domain databases

Gene3Di3.20.19.10. 1 hit.
3.30.499.10. 3 hits.
3.40.1060.10. 1 hit.
InterProiIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015934. Aconitase/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR006249. Aconitase/IRP2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERiPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF1. PTHR11670:SF1. 1 hit.
PfamiPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSiPR00415. ACONITASE.
SUPFAMiSSF52016. SSF52016. 1 hit.
SSF53732. SSF53732. 1 hit.
TIGRFAMsiTIGR01341. aconitase_1. 1 hit.
PROSITEiPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus cereus G9842."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G9842Imported.

Entry informationi

Entry nameiB7ISF5_BACC2
AccessioniPrimary (citable) accession number: B7ISF5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 22, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.