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B7IS43 (B7IS43_BACC2) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase 1 HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase 1 HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase 1 HAMAP MF_00435
Gene names
Name:ilvC2 EMBL ACK93448.1
Synonyms:ilvC1 HAMAP MF_00435
Ordered Locus Names:BCG9842_B3489
OrganismBacillus cereus (strain G9842) [Complete proteome] [HAMAP]
Taxonomic identifier405531 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1061 By similarity HAMAP MF_00435

Sequences

Sequence LengthMass (Da)Tools
B7IS43 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 8EBAF2D3C57F1D1A

FASTA33536,961
        10         20         30         40         50         60 
MKTYYEKDAN VELLQGKTVA VVGYGSQGHA QAQNLRDSGV EVVVGVRPGK SYEVAKADGF 

        70         80         90        100        110        120 
EVMSVSEAVR TAQVVQMLLP DEQQAYVYKA EVEENLREGH MLLFSHGFNI HFGQINPPSY 

       130        140        150        160        170        180 
VDVAMVAPKS PGHLVRRVFQ EGNGVPALVA VHQDATGTAL SLALAYAKGV GCTRAGVIET 

       190        200        210        220        230        240 
TFQEETETDL FGEQAVLCGG VTALVKAGFE TLTEGGYRPE IAYFECLHEL KLIVDLMYEG 

       250        260        270        280        290        300 
GLTNMRHSIS DTAEFGDYVT GSRIVTDETK KEMKRVLTEI QQGEFAKKWI LENQAGRPTY 

       310        320        330 
NAMKKAERNH QLEKVGAELR EMMSWIHAPK ELVKK

« Hide

References

[1]"Genome sequence of Bacillus cereus G9842."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001186 Genomic DNA. Translation: ACK93448.1.
RefSeqYP_002445233.1. NC_011772.1.

3D structure databases

ProteinModelPortalB7IS43.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7IS43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000104578; EBBACP00000100148; EBBACG00000104571.
GeneID7183128.
GenomeReviewsGene locus BCG9842_B3489 in contig CP001186_GR.
KEGGbcg:BCG9842_B3489.
PATRIC18899075. VBIBacCer50903_1693.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000000943.
HOGENOMHBG286525.
OMARPGKSYE.
ProtClustDBPRK13403.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB7IS43_BACC2
AccessionPrimary (citable) accession number: B7IS43
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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