SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7INE4

- ARSC_BACC2

UniProt

B7INE4 - ARSC_BACC2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein ArsC

Gene
arsC, BCG9842_B2062
Organism
Bacillus cereus (strain G9842)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111Nucleophile; for reductase activity and phosphatase activity By similarity
Active sitei83 – 831Nucleophile; for reductase activity By similarity
Active sitei90 – 901Nucleophile; for reductase activity By similarity

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciBCER405531:GI5L-3210-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase (EC:1.20.4.-)
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Gene namesi
Name:arsC
Ordered Locus Names:BCG9842_B2062
OrganismiBacillus cereus (strain G9842)
Taxonomic identifieri405531 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000006744: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134Protein ArsCUniRule annotationPRO_1000186115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi11 ↔ 83Redox-active; alternate By similarity
Disulfide bondi83 ↔ 90Redox-active; alternate By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405531.BCG9842_B2062.

Structurei

3D structure databases

ProteinModelPortaliB7INE4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273093.
KOiK03741.
OMAiGDRYEAY.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

B7INE4-1 [UniParc]FASTAAdd to Basket

« Hide

MENKKTIYFL CTGNSCRSQM AEAWGKQFLE DKWNVYSAGI EAHGVNPNAI    50
KAMNEVNIDI TNQTSDIIDA TILNSADLVV TLCSHADAVC PSTPPHVNRV 100
HWGFDDPAGK EWSEFQRVRD EIGEHIKRFS ETGE 134
Length:134
Mass (Da):15,011
Last modified:February 10, 2009 - v1
Checksum:i489F0E9BF9C60615
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001186 Genomic DNA. Translation: ACK97207.1.
RefSeqiYP_002446654.1. NC_011772.1.

Genome annotation databases

EnsemblBacteriaiACK97207; ACK97207; BCG9842_B2062.
GeneIDi7185292.
KEGGibcg:BCG9842_B2062.
PATRICi18901921. VBIBacCer50903_3113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001186 Genomic DNA. Translation: ACK97207.1 .
RefSeqi YP_002446654.1. NC_011772.1.

3D structure databases

ProteinModelPortali B7INE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405531.BCG9842_B2062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK97207 ; ACK97207 ; BCG9842_B2062 .
GeneIDi 7185292.
KEGGi bcg:BCG9842_B2062.
PATRICi 18901921. VBIBacCer50903_3113.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273093.
KOi K03741.
OMAi GDRYEAY.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci BCER405531:GI5L-3210-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus G9842."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G9842.

Entry informationi

Entry nameiARSC_BACC2
AccessioniPrimary (citable) accession number: B7INE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi