Reviewed, UniProtKB/Swiss-Prot B7IM74 (TRPC_BACC2)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BCG9842_B4050

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_1000117769

Sequences

	Sequence		Length	Mass (Da)
	B7IM74-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 8698CCDAEB298AAA	FASTA	253	28,320
	10 20 30 40 50 60 MGTILDKIVE QKKKEVAELY ETYTPVKTKR KTHSLVEALQ QFTVIAEVKR ASPSKGDINL 70 80 90 100 110 120 HVDVRKQVGT YEDCGAGAVS VLTDGQFFKG SFHDLQTARE ESNIPLLCKD FIIDKIQIDR 130 140 150 160 170 180 AYETGADIIL LIVAALTKEK LKELYSYVLE KGLEAIVEVH DEQELETAIQ LNPHVIGINN 190 200 210 220 230 240 RNLKTFEVDL SQTEKLGKRL NEEKLLWISE SGIHSKEDIT RVKRAGAKGV LVGEALMTSS 250 SISSFFEDCK VNI

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001186 Genomic DNA. Translation: ACK97912.1.
RefSeq	YP_002444686.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7185154.
GenomeReviews	Gene locus BCG9842_B4050 in contig CP001186_GR.
KEGG	bcg:BCG9842_B4050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
OMA	PLLCKDF.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACC2

Accession

Primary (citable) accession number: B7IM74

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	February 9, 2010
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)