B7ILE8 (PRPE_BACC2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical]
EC=3.6.1.17

Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
Short name=Diadenosine tetraphosphatase

Gene names

Name:	prpE
Ordered Locus Names:	BCG9842_B4084

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Asymmetrically hydrolyzes Ap4p to yield AMP and ATP By similarity. HAMAP MF_01443
Catalytic activity	P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP. HAMAP MF_01443
Cofactor	Nickel By similarity. HAMAP MF_01443
Sequence similarities	Belongs to the prpE family.

Ontologies

Keywords
Ligand	Nickel
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Inferred from electronic annotation. Source: EC nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Bis(5'-nucleosyl)-tetraphosphatase prpE [asymmetrical] HAMAP MF_01443		PRO_1000145928

Sequences

	Sequence		Length	Mass (Da)
	B7ILE8 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 29419ED342A04096	FASTA	246	28,263
	10 20 30 40 50 60 MKYDIIGDIH GCFQEFQNLT EKLGYNWSSG LPIHPEQRKL AFVGDITDRG PHSLRMIEIV 70 80 90 100 110 120 WELVIHKKEA YYAPGNHCNK LYRFFLGRNV TIAHGLETTV AEYEALPSHK QNIIKEKFIT 130 140 150 160 170 180 LYEQSPLYHI LDEKKVIVCH AGIRQDYIGR RDKKVQTFVL YGDITGEKHA DGSPVRRDWA 190 200 210 220 230 240 QEYKGQAWIV YGHTPVKEPR FVNQTVNIDT GAVFGGKLTG LRYPEMETIS VPSSLPFVAE KFRPIS

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G9842.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001186 Genomic DNA. Translation: ACK98023.1.
RefSeq	YP_002444652.1. NC_011772.1.
3D structure databases
ProteinModelPortal	B7ILE8.
ModBase	Search...
Protein-protein interaction databases
STRING	B7ILE8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000106550; EBBACP00000101876; EBBACG00000106543.
GeneID	7186498.
GenomeReviews	Gene locus BCG9842_B4084 in contig CP001186_GR.
KEGG	bcg:BCG9842_B4084.
PATRIC	18897903. VBIBacCer50903_1109.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002430.
HOGENOM	HBG724457.
OMA	YVPGNHC.
ProtClustDB	PRK13625.
Family and domain databases
HAMAP	MF_01443. PrpE. [Tree]
InterPro	IPR023937. Bis(5'-nucleosyl)-tetraP_PrpE. IPR004843. Metallo_PEstase_dom. [Graphical view]
KO	K01090.
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRPE_BACC2

Accession

Primary (citable) accession number: B7ILE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program