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B7IKP3 (COAW_BACC2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type II pantothenate kinase

EC=2.7.1.33
Alternative name(s):
PanK-II
Pantothenic acid kinase
Gene names
Name:coaW
Ordered Locus Names:BCG9842_B2329
OrganismBacillus cereus (strain G9842) [Complete proteome] [HAMAP]
Taxonomic identifier405531 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis By similarity. HAMAP-Rule MF_01273

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP-Rule MF_01273

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP-Rule MF_01273

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01273

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01273.

Sequence similarities

Belongs to the type II pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pantothenate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Type II pantothenate kinase HAMAP-Rule MF_01273
PRO_1000140207

Regions

Nucleotide binding8 – 158ATP By similarity
Nucleotide binding127 – 1315ATP By similarity

Sites

Active site761Proton acceptor By similarity
Binding site1051ATP By similarity
Binding site1431ATP By similarity
Binding site2301ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B7IKP3 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 652C3FFC0E5D47DA

FASTA27329,826
        10         20         30         40         50         60 
MERTIGIDAG GTLTKIAYFN EKRLLTFEKF YSHEQHKIID WIKNNNGIKQ ICITGGKSKL 

        70         80         90        100        110        120 
LQQLLTGSYK IIELNEFEAT LAGVQYILKE EKHAIRNFIL TNIGTGTSIH YVYNEQYIRA 

       130        140        150        160        170        180 
GGTGVGGGTI MGLSKLLTNI DHFEDVIPLT KVGSRKELDI TVGDIYGGIL SPIDNNLTAS 

       190        200        210        220        230        240 
NFGKAAITES NNSSSDILAT VQGLVGEVVT ALSLQFAETK NIEHIIYIGS TLCNNVQLQH 

       250        260        270 
IISSYTEYQN KTPIFLQDGG NSGAIGALLH ATK 

« Hide

References

[1]"Genome sequence of Bacillus cereus G9842."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G9842.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001186 Genomic DNA. Translation: ACK94042.1.
RefSeqYP_002446388.1. NC_011772.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405531.BCG9842_B2329.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK94042; ACK94042; BCG9842_B2329.
GeneID7181817.
KEGGbcg:BCG9842_B2329.
PATRIC18901399. VBIBacCer50903_2853.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG5146.
HOGENOMHOG000092412.
KOK09680.
OMAKFYSNEQ.
OrthoDBEOG61S33B.

Enzyme and pathway databases

BioCycBCER405531:GI5L-2944-MONOMER.
UniPathwayUPA00241; UER00352.

Family and domain databases

HAMAPMF_01273. Pantothen_kinase_2.
InterProIPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view]
PfamPF03630. Fumble. 1 hit.
[Graphical view]
PIRSFPIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsTIGR00555. panK_eukar. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAW_BACC2
AccessionPrimary (citable) accession number: B7IKP3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways