Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Type II pantothenate kinase

Gene

coaW

Organism
Bacillus cereus (strain G9842)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathway:icoenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type II pantothenate kinase (coaW), Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptorUniRule annotation
Binding sitei105 – 1051ATPUniRule annotation
Binding sitei143 – 1431ATPUniRule annotation
Binding sitei230 – 2301ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation
Nucleotide bindingi127 – 1315ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER405531:GI5L-2944-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaWUniRule annotation
Ordered Locus Names:BCG9842_B2329
OrganismiBacillus cereus (strain G9842)
Taxonomic identifieri405531 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000006744 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Type II pantothenate kinasePRO_1000140207Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5146.
HOGENOMiHOG000092412.
KOiK09680.
OMAiKFYSNEQ.
OrthoDBiEOG61S33B.

Family and domain databases

HAMAPiMF_01273. Pantothen_kinase_2.
InterProiIPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

B7IKP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTIGIDAG GTLTKIAYFN EKRLLTFEKF YSHEQHKIID WIKNNNGIKQ
60 70 80 90 100
ICITGGKSKL LQQLLTGSYK IIELNEFEAT LAGVQYILKE EKHAIRNFIL
110 120 130 140 150
TNIGTGTSIH YVYNEQYIRA GGTGVGGGTI MGLSKLLTNI DHFEDVIPLT
160 170 180 190 200
KVGSRKELDI TVGDIYGGIL SPIDNNLTAS NFGKAAITES NNSSSDILAT
210 220 230 240 250
VQGLVGEVVT ALSLQFAETK NIEHIIYIGS TLCNNVQLQH IISSYTEYQN
260 270
KTPIFLQDGG NSGAIGALLH ATK
Length:273
Mass (Da):29,826
Last modified:February 10, 2009 - v1
Checksum:i652C3FFC0E5D47DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001186 Genomic DNA. Translation: ACK94042.1.
RefSeqiWP_000442499.1. NC_011772.1.

Genome annotation databases

EnsemblBacteriaiACK94042; ACK94042; BCG9842_B2329.
KEGGibcg:BCG9842_B2329.
PATRICi18901399. VBIBacCer50903_2853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001186 Genomic DNA. Translation: ACK94042.1.
RefSeqiWP_000442499.1. NC_011772.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK94042; ACK94042; BCG9842_B2329.
KEGGibcg:BCG9842_B2329.
PATRICi18901399. VBIBacCer50903_2853.

Phylogenomic databases

eggNOGiCOG5146.
HOGENOMiHOG000092412.
KOiK09680.
OMAiKFYSNEQ.
OrthoDBiEOG61S33B.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciBCER405531:GI5L-2944-MONOMER.

Family and domain databases

HAMAPiMF_01273. Pantothen_kinase_2.
InterProiIPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus cereus G9842."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G9842.

Entry informationi

Entry nameiCOAW_BACC2
AccessioniPrimary (citable) accession number: B7IKP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: July 22, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.