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B7IKP3

- COAW_BACC2

UniProt

B7IKP3 - COAW_BACC2

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Protein

Type II pantothenate kinase

Gene

coaW

Organism
Bacillus cereus (strain G9842)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptorUniRule annotation
Binding sitei105 – 1051ATPUniRule annotation
Binding sitei143 – 1431ATPUniRule annotation
Binding sitei230 – 2301ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158ATPUniRule annotation
Nucleotide bindingi127 – 1315ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. pantothenate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER405531:GI5L-2944-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaWUniRule annotation
Ordered Locus Names:BCG9842_B2329
OrganismiBacillus cereus (strain G9842)
Taxonomic identifieri405531 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000006744: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Type II pantothenate kinasePRO_1000140207Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi405531.BCG9842_B2329.

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5146.
HOGENOMiHOG000092412.
KOiK09680.
OMAiKFYSNEQ.
OrthoDBiEOG61S33B.

Family and domain databases

HAMAPiMF_01273. Pantothen_kinase_2.
InterProiIPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view]
PfamiPF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

B7IKP3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERTIGIDAG GTLTKIAYFN EKRLLTFEKF YSHEQHKIID WIKNNNGIKQ
60 70 80 90 100
ICITGGKSKL LQQLLTGSYK IIELNEFEAT LAGVQYILKE EKHAIRNFIL
110 120 130 140 150
TNIGTGTSIH YVYNEQYIRA GGTGVGGGTI MGLSKLLTNI DHFEDVIPLT
160 170 180 190 200
KVGSRKELDI TVGDIYGGIL SPIDNNLTAS NFGKAAITES NNSSSDILAT
210 220 230 240 250
VQGLVGEVVT ALSLQFAETK NIEHIIYIGS TLCNNVQLQH IISSYTEYQN
260 270
KTPIFLQDGG NSGAIGALLH ATK
Length:273
Mass (Da):29,826
Last modified:February 10, 2009 - v1
Checksum:i652C3FFC0E5D47DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001186 Genomic DNA. Translation: ACK94042.1.
RefSeqiYP_002446388.1. NC_011772.1.

Genome annotation databases

EnsemblBacteriaiACK94042; ACK94042; BCG9842_B2329.
GeneIDi7181817.
KEGGibcg:BCG9842_B2329.
PATRICi18901399. VBIBacCer50903_2853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001186 Genomic DNA. Translation: ACK94042.1 .
RefSeqi YP_002446388.1. NC_011772.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405531.BCG9842_B2329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK94042 ; ACK94042 ; BCG9842_B2329 .
GeneIDi 7181817.
KEGGi bcg:BCG9842_B2329.
PATRICi 18901399. VBIBacCer50903_2853.

Phylogenomic databases

eggNOGi COG5146.
HOGENOMi HOG000092412.
KOi K09680.
OMAi KFYSNEQ.
OrthoDBi EOG61S33B.

Enzyme and pathway databases

UniPathwayi UPA00241 ; UER00352 .
BioCyci BCER405531:GI5L-2944-MONOMER.

Family and domain databases

HAMAPi MF_01273. Pantothen_kinase_2.
InterProi IPR004567. Type_II_PanK.
IPR011602. Type_II_PanK_bac.
[Graphical view ]
Pfami PF03630. Fumble. 1 hit.
[Graphical view ]
PIRSFi PIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMsi TIGR00555. panK_eukar. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus G9842."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G9842.

Entry informationi

Entry nameiCOAW_BACC2
AccessioniPrimary (citable) accession number: B7IKP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3