B7IKP3 (COAW_BACC2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type II pantothenate kinase
EC=2.7.1.33

Alternative name(s):
PanK-II
Pantothenic acid kinase

Gene names

Name:	coaW
Ordered Locus Names:	BCG9842_B2329

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis By similarity. HAMAP-Rule MF_01273
Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP-Rule MF_01273
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP-Rule MF_01273
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01273
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01273.
Sequence similarities	Belongs to the type II pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP pantothenate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Type II pantothenate kinase HAMAP-Rule MF_01273		PRO_1000140207
Regions
	Nucleotide binding	8 – 15	8	ATP By similarity
	Nucleotide binding	127 – 131	5	ATP By similarity
Sites
	Active site	76	1	Proton acceptor By similarity
	Binding site	105	1	ATP By similarity
	Binding site	143	1	ATP By similarity
	Binding site	230	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7IKP3 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 652C3FFC0E5D47DA	FASTA	273	29,826
	10 20 30 40 50 60 MERTIGIDAG GTLTKIAYFN EKRLLTFEKF YSHEQHKIID WIKNNNGIKQ ICITGGKSKL 70 80 90 100 110 120 LQQLLTGSYK IIELNEFEAT LAGVQYILKE EKHAIRNFIL TNIGTGTSIH YVYNEQYIRA 130 140 150 160 170 180 GGTGVGGGTI MGLSKLLTNI DHFEDVIPLT KVGSRKELDI TVGDIYGGIL SPIDNNLTAS 190 200 210 220 230 240 NFGKAAITES NNSSSDILAT VQGLVGEVVT ALSLQFAETK NIEHIIYIGS TLCNNVQLQH 250 260 270 IISSYTEYQN KTPIFLQDGG NSGAIGALLH ATK

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G9842.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001186 Genomic DNA. Translation: ACK94042.1.
RefSeq	YP_002446388.1. NC_011772.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	405531.BCG9842_B2329.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK94042; ACK94042; BCG9842_B2329.
GeneID	7181817.
KEGG	bcg:BCG9842_B2329.
PATRIC	18901399. VBIBacCer50903_2853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG5146.
HOGENOM	HOG000092412.
KO	K09680.
OMA	KVKHIYK.
ProtClustDB	PRK13317.
Enzyme and pathway databases
BioCyc	BCER405531:GI5L-2944-MONOMER.
UniPathway	UPA00241; UER00352.
Family and domain databases
HAMAP	MF_01273. Pantothen_kinase_2.
InterPro	IPR011602. Pantothenate_kinase_bac. IPR004567. Type_II_PanK. [Graphical view]
Pfam	PF03630. Fumble. 1 hit. [Graphical view]
PIRSF	PIRSF036940. PanK_bac_aCoA. 1 hit.
TIGRFAMs	TIGR00555. panK_eukar. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAW_BACC2

Accession

Primary (citable) accession number: B7IKP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program