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B7IKP3

- COAW_BACC2

UniProt

B7IKP3 - COAW_BACC2

Protein

Type II pantothenate kinase

Gene

coaW

Organism
Bacillus cereus (strain G9842)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Proton acceptorUniRule annotation
    Binding sitei105 – 1051ATPUniRule annotation
    Binding sitei143 – 1431ATPUniRule annotation
    Binding sitei230 – 2301ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158ATPUniRule annotation
    Nucleotide bindingi127 – 1315ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. pantothenate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Coenzyme A biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCER405531:GI5L-2944-MONOMER.
    UniPathwayiUPA00241; UER00352.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type II pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
    Alternative name(s):
    PanK-IIUniRule annotation
    Pantothenic acid kinaseUniRule annotation
    Gene namesi
    Name:coaWUniRule annotation
    Ordered Locus Names:BCG9842_B2329
    OrganismiBacillus cereus (strain G9842)
    Taxonomic identifieri405531 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000006744: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Type II pantothenate kinasePRO_1000140207Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405531.BCG9842_B2329.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II pantothenate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5146.
    HOGENOMiHOG000092412.
    KOiK09680.
    OMAiKFYSNEQ.
    OrthoDBiEOG61S33B.

    Family and domain databases

    HAMAPiMF_01273. Pantothen_kinase_2.
    InterProiIPR004567. Type_II_PanK.
    IPR011602. Type_II_PanK_bac.
    [Graphical view]
    PfamiPF03630. Fumble. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036940. PanK_bac_aCoA. 1 hit.
    TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7IKP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERTIGIDAG GTLTKIAYFN EKRLLTFEKF YSHEQHKIID WIKNNNGIKQ    50
    ICITGGKSKL LQQLLTGSYK IIELNEFEAT LAGVQYILKE EKHAIRNFIL 100
    TNIGTGTSIH YVYNEQYIRA GGTGVGGGTI MGLSKLLTNI DHFEDVIPLT 150
    KVGSRKELDI TVGDIYGGIL SPIDNNLTAS NFGKAAITES NNSSSDILAT 200
    VQGLVGEVVT ALSLQFAETK NIEHIIYIGS TLCNNVQLQH IISSYTEYQN 250
    KTPIFLQDGG NSGAIGALLH ATK 273
    Length:273
    Mass (Da):29,826
    Last modified:February 10, 2009 - v1
    Checksum:i652C3FFC0E5D47DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001186 Genomic DNA. Translation: ACK94042.1.
    RefSeqiYP_002446388.1. NC_011772.1.

    Genome annotation databases

    EnsemblBacteriaiACK94042; ACK94042; BCG9842_B2329.
    GeneIDi7181817.
    KEGGibcg:BCG9842_B2329.
    PATRICi18901399. VBIBacCer50903_2853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001186 Genomic DNA. Translation: ACK94042.1 .
    RefSeqi YP_002446388.1. NC_011772.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405531.BCG9842_B2329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK94042 ; ACK94042 ; BCG9842_B2329 .
    GeneIDi 7181817.
    KEGGi bcg:BCG9842_B2329.
    PATRICi 18901399. VBIBacCer50903_2853.

    Phylogenomic databases

    eggNOGi COG5146.
    HOGENOMi HOG000092412.
    KOi K09680.
    OMAi KFYSNEQ.
    OrthoDBi EOG61S33B.

    Enzyme and pathway databases

    UniPathwayi UPA00241 ; UER00352 .
    BioCyci BCER405531:GI5L-2944-MONOMER.

    Family and domain databases

    HAMAPi MF_01273. Pantothen_kinase_2.
    InterProi IPR004567. Type_II_PanK.
    IPR011602. Type_II_PanK_bac.
    [Graphical view ]
    Pfami PF03630. Fumble. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036940. PanK_bac_aCoA. 1 hit.
    TIGRFAMsi TIGR00555. panK_eukar. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus G9842."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G9842.

    Entry informationi

    Entry nameiCOAW_BACC2
    AccessioniPrimary (citable) accession number: B7IKP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3