B7IIY3 (CLPX_BACC2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX

Gene names

Name:	clpX
Ordered Locus Names:	BCG9842_B0644

Organism

Bacillus cereus (strain G9842) [Complete proteome] [HAMAP]

Taxonomic identifier

405531 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175
Subunit structure	Heterodimer of ClpP and ClpX By similarity.
Sequence similarities	Belongs to the ClpX chaperone family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175		PRO_1000189682
Regions
	Zinc finger	13 – 38	26	C4-type HAMAP-Rule MF_00175
	Nucleotide binding	116 – 123	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B7IIY3 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: CEEB7832141536FB	FASTA	419	46,242
	10 20 30 40 50 60 MFKFNDEKGQ LKCSFCGKTQ TQVRKLVAGP GVYICDECIE LCTEIVQEEL AKDEEVEFKD 70 80 90 100 110 120 VPKPVEIREI LDEYVIGQDS AKKALAVAVY NHYKRINSNS KIDDVELAKS NIALIGPTGS 130 140 150 160 170 180 GKTLLAQTLA RILNVPFAIA DATSLTEAGY VGEDVENILL KLIQAADYDV EKAEKGIIYI 190 200 210 220 230 240 DEIDKVARKS ENPSITRDVS GEGVQQALLK ILEGTVASVP PQGGRKHPHQ EFIQIDTTNI 250 260 270 280 290 300 LFICGGAFDG IEPIIKRRLG EKVIGFGSEK KNADVNEKHV LSHVLPEDLL RFGLIPEFIG 310 320 330 340 350 360 RLPVIANLEP LDEDALVDIL TKPKNALVKQ FQKLLELDDV ELEFEEGALI EIAKKAIERK 370 380 390 400 410 TGARGLRSII EGLMLDVMFE LPSRKDIEKC ILTKETVADN EPPKLVLQDG TVLDTKTSA

References

[1]	"Genome sequence of Bacillus cereus G9842." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G9842.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001186 Genomic DNA. Translation: ACK95053.1.
RefSeq	YP_002448051.1. NC_011772.1.
3D structure databases
ProteinModelPortal	B7IIY3.
SMR	B7IIY3. Positions 11-50.
ModBase	Search...
Protein-protein interaction databases
STRING	405531.BCG9842_B0644.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK95053; ACK95053; BCG9842_B0644.
GeneID	7184262.
KEGG	bcg:BCG9842_B0644.
PATRIC	18904712. VBIBacCer50903_4506.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1219.
HOGENOM	HOG000010093.
KO	K03544.
OMA	IMFEVPS.
ProtClustDB	PRK05342.
Enzyme and pathway databases
BioCyc	BCER405531:GI5L-2461-MONOMER.
Family and domain databases
HAMAP	MF_00175. ClpX.
InterPro	IPR003593. AAA+_ATPase. IPR013093. ATPase_AAA-2. IPR019489. Clp_ATPase_C. IPR004487. Clp_protease_ATP-bd_su_ClpX. IPR010603. Znf_CppX_C4. [Graphical view]
PANTHER	PTHR11262:SF4. PTHR11262:SF4. 1 hit.
Pfam	PF07724. AAA_2. 1 hit. PF10431. ClpB_D2-small. 1 hit. PF06689. zf-C4_ClpX. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM01086. ClpB_D2-small. 1 hit. SM00994. zf-C4_ClpX. 1 hit. [Graphical view]
TIGRFAMs	TIGR00382. clpX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CLPX_BACC2

Accession

Primary (citable) accession number: B7IIY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program