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B7IIY3 (CLPX_BACC2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:BCG9842_B0644
OrganismBacillus cereus (strain G9842) [Complete proteome] [HAMAP]
Taxonomic identifier405531 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_1000189682

Regions

Zinc finger13 – 3826C4-type HAMAP-Rule MF_00175
Nucleotide binding117 – 1248ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B7IIY3 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: CEEB7832141536FB

FASTA41946,242
        10         20         30         40         50         60 
MFKFNDEKGQ LKCSFCGKTQ TQVRKLVAGP GVYICDECIE LCTEIVQEEL AKDEEVEFKD 

        70         80         90        100        110        120 
VPKPVEIREI LDEYVIGQDS AKKALAVAVY NHYKRINSNS KIDDVELAKS NIALIGPTGS 

       130        140        150        160        170        180 
GKTLLAQTLA RILNVPFAIA DATSLTEAGY VGEDVENILL KLIQAADYDV EKAEKGIIYI 

       190        200        210        220        230        240 
DEIDKVARKS ENPSITRDVS GEGVQQALLK ILEGTVASVP PQGGRKHPHQ EFIQIDTTNI 

       250        260        270        280        290        300 
LFICGGAFDG IEPIIKRRLG EKVIGFGSEK KNADVNEKHV LSHVLPEDLL RFGLIPEFIG 

       310        320        330        340        350        360 
RLPVIANLEP LDEDALVDIL TKPKNALVKQ FQKLLELDDV ELEFEEGALI EIAKKAIERK 

       370        380        390        400        410 
TGARGLRSII EGLMLDVMFE LPSRKDIEKC ILTKETVADN EPPKLVLQDG TVLDTKTSA 

« Hide

References

[1]"Genome sequence of Bacillus cereus G9842."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G9842.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001186 Genomic DNA. Translation: ACK95053.1.
RefSeqYP_002448051.1. NC_011772.1.

3D structure databases

ProteinModelPortalB7IIY3.
SMRB7IIY3. Positions 11-50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405531.BCG9842_B0644.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK95053; ACK95053; BCG9842_B0644.
GeneID7184262.
KEGGbcg:BCG9842_B0644.
PATRIC18904712. VBIBacCer50903_4506.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMADIMFEVP.
OrthoDBEOG625JZK.

Enzyme and pathway databases

BioCycBCER405531:GI5L-4608-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_BACC2
AccessionPrimary (citable) accession number: B7IIY3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families