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B7IG29 (FTHS_THEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:THA_555
OrganismThermosipho africanus (strain TCF52B) [Complete proteome] [HAMAP]
Taxonomic identifier484019 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000146705

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B7IG29 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 861332D608F65B9E

FASTA55159,873
        10         20         30         40         50         60 
MKTDIEIARE AKLEKITKIA EKIDISEEYV EPYGKYIAKV DLKIWEKVKN NKDGKLILVT 

        70         80         90        100        110        120 
AMTPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP VFGIKGGAAG GGYSQVLPME 

       130        140        150        160        170        180 
NINLHFTGDI HAVSAAHNLI SAVIDAHIKF GNELGIDPTR IYWKRTIDMN DRALRNIVVG 

       190        200        210        220        230        240 
LGGSANGQPR EDGFIITAAS EIMAILCLAK DLKDLKERLS NIVVAQSYDK KLIKVKDLKI 

       250        260        270        280        290        300 
EGALAVLLKD AIKPNLVQTI ENTPAFVHGG PFANIAHGTN SIIATKLALK LSDYVVTEAG 

       310        320        330        340        350        360 
FAADLGAEKF LDFVSPTAGY DVNAVVVVAT IKALKYHGGV KKDELDNENV EAMLKGMENL 

       370        380        390        400        410        420 
RVHVENLKKY NVPVIVALNV FGSDTQRELD EFSKNCEIPH ALVYAFEKGG EGAVDLANLV 

       430        440        450        460        470        480 
LENIKESQYK PLITSEMSLE EKIETLAKEI YRAGNVIYTD KAKSKLKFLR KHGYDTLPVI 

       490        500        510        520        530        540 
VAKTQSSISD DPKKINAPSG YTFTIRDFEL SAGAGFIVAL AGDIMRMPGL SKIPNAVNID 

       550 
IDEEGNIIGL S 

« Hide

References

[1]"The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TCF52B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001185 Genomic DNA. Translation: ACJ75043.1.
RefSeqYP_002334384.1. NC_011653.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING484019.THA_555.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ75043; ACJ75043; THA_555.
GeneID7071854.
KEGGtaf:THA_555.
PATRIC23918066. VBITheAfr129358_0564.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMADPKKINA.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycTAFR484019:GJOH-568-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THEAB
AccessionPrimary (citable) accession number: B7IG29
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways