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B7IG29

- FTHS_THEAB

UniProt

B7IG29 - FTHS_THEAB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTAFR484019:GJOH-568-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:THA_555
    OrganismiThermosipho africanus (strain TCF52B)
    Taxonomic identifieri484019 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000002453: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_1000146705Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi484019.THA_555.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiDPKKINA.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7IG29-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIARE AKLEKITKIA EKIDISEEYV EPYGKYIAKV DLKIWEKVKN    50
    NKDGKLILVT AMTPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP 100
    VFGIKGGAAG GGYSQVLPME NINLHFTGDI HAVSAAHNLI SAVIDAHIKF 150
    GNELGIDPTR IYWKRTIDMN DRALRNIVVG LGGSANGQPR EDGFIITAAS 200
    EIMAILCLAK DLKDLKERLS NIVVAQSYDK KLIKVKDLKI EGALAVLLKD 250
    AIKPNLVQTI ENTPAFVHGG PFANIAHGTN SIIATKLALK LSDYVVTEAG 300
    FAADLGAEKF LDFVSPTAGY DVNAVVVVAT IKALKYHGGV KKDELDNENV 350
    EAMLKGMENL RVHVENLKKY NVPVIVALNV FGSDTQRELD EFSKNCEIPH 400
    ALVYAFEKGG EGAVDLANLV LENIKESQYK PLITSEMSLE EKIETLAKEI 450
    YRAGNVIYTD KAKSKLKFLR KHGYDTLPVI VAKTQSSISD DPKKINAPSG 500
    YTFTIRDFEL SAGAGFIVAL AGDIMRMPGL SKIPNAVNID IDEEGNIIGL 550
    S 551
    Length:551
    Mass (Da):59,873
    Last modified:February 10, 2009 - v1
    Checksum:i861332D608F65B9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ75043.1.
    RefSeqiWP_012579645.1. NC_011653.1.
    YP_002334384.1. NC_011653.1.

    Genome annotation databases

    EnsemblBacteriaiACJ75043; ACJ75043; THA_555.
    GeneIDi7071854.
    KEGGitaf:THA_555.
    PATRICi23918066. VBITheAfr129358_0564.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ75043.1 .
    RefSeqi WP_012579645.1. NC_011653.1.
    YP_002334384.1. NC_011653.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484019.THA_555.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ75043 ; ACJ75043 ; THA_555 .
    GeneIDi 7071854.
    KEGGi taf:THA_555.
    PATRICi 23918066. VBITheAfr129358_0564.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi DPKKINA.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TAFR484019:GJOH-568-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
      Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
      J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCF52B.

    Entry informationi

    Entry nameiFTHS_THEAB
    AccessioniPrimary (citable) accession number: B7IG29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3