Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7IG29

- FTHS_THEAB

UniProt

B7IG29 - FTHS_THEAB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-568-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:THA_555
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000002453: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_1000146705Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_555.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiDPKKINA.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7IG29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIARE AKLEKITKIA EKIDISEEYV EPYGKYIAKV DLKIWEKVKN
60 70 80 90 100
NKDGKLILVT AMTPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP
110 120 130 140 150
VFGIKGGAAG GGYSQVLPME NINLHFTGDI HAVSAAHNLI SAVIDAHIKF
160 170 180 190 200
GNELGIDPTR IYWKRTIDMN DRALRNIVVG LGGSANGQPR EDGFIITAAS
210 220 230 240 250
EIMAILCLAK DLKDLKERLS NIVVAQSYDK KLIKVKDLKI EGALAVLLKD
260 270 280 290 300
AIKPNLVQTI ENTPAFVHGG PFANIAHGTN SIIATKLALK LSDYVVTEAG
310 320 330 340 350
FAADLGAEKF LDFVSPTAGY DVNAVVVVAT IKALKYHGGV KKDELDNENV
360 370 380 390 400
EAMLKGMENL RVHVENLKKY NVPVIVALNV FGSDTQRELD EFSKNCEIPH
410 420 430 440 450
ALVYAFEKGG EGAVDLANLV LENIKESQYK PLITSEMSLE EKIETLAKEI
460 470 480 490 500
YRAGNVIYTD KAKSKLKFLR KHGYDTLPVI VAKTQSSISD DPKKINAPSG
510 520 530 540 550
YTFTIRDFEL SAGAGFIVAL AGDIMRMPGL SKIPNAVNID IDEEGNIIGL

S
Length:551
Mass (Da):59,873
Last modified:February 10, 2009 - v1
Checksum:i861332D608F65B9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75043.1.
RefSeqiWP_012579645.1. NC_011653.1.
YP_002334384.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ75043; ACJ75043; THA_555.
GeneIDi7071854.
KEGGitaf:THA_555.
PATRICi23918066. VBITheAfr129358_0564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75043.1 .
RefSeqi WP_012579645.1. NC_011653.1.
YP_002334384.1. NC_011653.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484019.THA_555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ75043 ; ACJ75043 ; THA_555 .
GeneIDi 7071854.
KEGGi taf:THA_555.
PATRICi 23918066. VBITheAfr129358_0564.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi DPKKINA.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TAFR484019:GJOH-568-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
    Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
    J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCF52B.

Entry informationi

Entry nameiFTHS_THEAB
AccessioniPrimary (citable) accession number: B7IG29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3