Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:THA_555
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeThermosipho
Proteomesi
  • UP000002453 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001467051 – 551Formate--tetrahydrofolate ligaseAdd BLAST551

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_555.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7IG29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIARE AKLEKITKIA EKIDISEEYV EPYGKYIAKV DLKIWEKVKN
60 70 80 90 100
NKDGKLILVT AMTPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP
110 120 130 140 150
VFGIKGGAAG GGYSQVLPME NINLHFTGDI HAVSAAHNLI SAVIDAHIKF
160 170 180 190 200
GNELGIDPTR IYWKRTIDMN DRALRNIVVG LGGSANGQPR EDGFIITAAS
210 220 230 240 250
EIMAILCLAK DLKDLKERLS NIVVAQSYDK KLIKVKDLKI EGALAVLLKD
260 270 280 290 300
AIKPNLVQTI ENTPAFVHGG PFANIAHGTN SIIATKLALK LSDYVVTEAG
310 320 330 340 350
FAADLGAEKF LDFVSPTAGY DVNAVVVVAT IKALKYHGGV KKDELDNENV
360 370 380 390 400
EAMLKGMENL RVHVENLKKY NVPVIVALNV FGSDTQRELD EFSKNCEIPH
410 420 430 440 450
ALVYAFEKGG EGAVDLANLV LENIKESQYK PLITSEMSLE EKIETLAKEI
460 470 480 490 500
YRAGNVIYTD KAKSKLKFLR KHGYDTLPVI VAKTQSSISD DPKKINAPSG
510 520 530 540 550
YTFTIRDFEL SAGAGFIVAL AGDIMRMPGL SKIPNAVNID IDEEGNIIGL

S
Length:551
Mass (Da):59,873
Last modified:February 10, 2009 - v1
Checksum:i861332D608F65B9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ75043.1.
RefSeqiWP_012579645.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ75043; ACJ75043; THA_555.
KEGGitaf:THA_555.
PATRICi23918066. VBITheAfr129358_0564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ75043.1.
RefSeqiWP_012579645.1. NC_011653.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi484019.THA_555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ75043; ACJ75043; THA_555.
KEGGitaf:THA_555.
PATRICi23918066. VBITheAfr129358_0564.

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTHS_THEAB
AccessioniPrimary (citable) accession number: B7IG29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.