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B7IFS1 (UPPP_THEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:THA_444
OrganismThermosipho africanus (strain TCF52B) [Complete proteome] [HAMAP]
Taxonomic identifier484019 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197417

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane74 – 9421Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane174 – 19421Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane228 – 24821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B7IFS1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 86BCDDF5DA29A534

FASTA24827,461
        10         20         30         40         50         60 
MNHIVLGLIQ GLTEFLPISS SGHLTLFSYL FNIEPNISNF AFLHLATLAA IIVFVWKEIV 

        70         80         90        100        110        120 
EILKGLFTLK KEYYSLVLKI IISTIPAAIF GFLFNSTIEN SFSNLKIISF FFLVTAASLF 

       130        140        150        160        170        180 
VSDKLKGKKD FFNISYIDAL IIGLFQMIAI FPGISRSGIT LFGALTVGLE REKALKYSFL 

       190        200        210        220        230        240 
MGIPVILGAG ILETSKIELN SYILISGLVA FLSGLLSLLI LKKLTISKKL KIFSYYCILI 


AIIAFFVG 

« Hide

References

[1]"The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TCF52B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001185 Genomic DNA. Translation: ACJ74935.1.
RefSeqYP_002334276.1. NC_011653.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING484019.THA_444.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ74935; ACJ74935; THA_444.
GeneID7070698.
KEGGtaf:THA_444.
PATRIC23917824. VBITheAfr129358_0444.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAPIVFDIY.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycTAFR484019:GJOH-452-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR001991. Na-dicarboxylate_symporter.
IPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
SUPFAMSSF118215. SSF118215. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_THEAB
AccessionPrimary (citable) accession number: B7IFS1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families