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B7IFS1

- UPPP_THEAB

UniProt

B7IFS1 - UPPP_THEAB

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. sodium:dicarboxylate symporter activity Source: InterPro
    2. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciTAFR484019:GJOH-452-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:THA_444
    OrganismiThermosipho africanus (strain TCF52B)
    Taxonomic identifieri484019 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000002453: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Undecaprenyl-diphosphatasePRO_1000197417Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi484019.THA_444.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalUniRule annotationAdd
    BLAST
    Transmembranei40 – 6021HelicalUniRule annotationAdd
    BLAST
    Transmembranei74 – 9421HelicalUniRule annotationAdd
    BLAST
    Transmembranei101 – 12121HelicalUniRule annotationAdd
    BLAST
    Transmembranei134 – 15421HelicalUniRule annotationAdd
    BLAST
    Transmembranei174 – 19421HelicalUniRule annotationAdd
    BLAST
    Transmembranei201 – 22121HelicalUniRule annotationAdd
    BLAST
    Transmembranei228 – 24821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiPIVFDIY.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR001991. Na-dicarboxylate_symporter.
    IPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    SUPFAMiSSF118215. SSF118215. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7IFS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHIVLGLIQ GLTEFLPISS SGHLTLFSYL FNIEPNISNF AFLHLATLAA    50
    IIVFVWKEIV EILKGLFTLK KEYYSLVLKI IISTIPAAIF GFLFNSTIEN 100
    SFSNLKIISF FFLVTAASLF VSDKLKGKKD FFNISYIDAL IIGLFQMIAI 150
    FPGISRSGIT LFGALTVGLE REKALKYSFL MGIPVILGAG ILETSKIELN 200
    SYILISGLVA FLSGLLSLLI LKKLTISKKL KIFSYYCILI AIIAFFVG 248
    Length:248
    Mass (Da):27,461
    Last modified:February 10, 2009 - v1
    Checksum:i86BCDDF5DA29A534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ74935.1.
    RefSeqiWP_012579584.1. NC_011653.1.
    YP_002334276.1. NC_011653.1.

    Genome annotation databases

    EnsemblBacteriaiACJ74935; ACJ74935; THA_444.
    GeneIDi7070698.
    KEGGitaf:THA_444.
    PATRICi23917824. VBITheAfr129358_0444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ74935.1 .
    RefSeqi WP_012579584.1. NC_011653.1.
    YP_002334276.1. NC_011653.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484019.THA_444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ74935 ; ACJ74935 ; THA_444 .
    GeneIDi 7070698.
    KEGGi taf:THA_444.
    PATRICi 23917824. VBITheAfr129358_0444.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi PIVFDIY.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci TAFR484019:GJOH-452-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR001991. Na-dicarboxylate_symporter.
    IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF118215. SSF118215. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
      Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
      J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCF52B.

    Entry informationi

    Entry nameiUPPP_THEAB
    AccessioniPrimary (citable) accession number: B7IFS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3