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B7IFS1

- UPPP_THEAB

UniProt

B7IFS1 - UPPP_THEAB

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, THA_444
Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. sodium:dicarboxylate symporter activity Source: InterPro
  2. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:THA_444
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000002453: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed predictionAdd
BLAST
Transmembranei40 – 6021Helical; Reviewed predictionAdd
BLAST
Transmembranei74 – 9421Helical; Reviewed predictionAdd
BLAST
Transmembranei101 – 12121Helical; Reviewed predictionAdd
BLAST
Transmembranei134 – 15421Helical; Reviewed predictionAdd
BLAST
Transmembranei174 – 19421Helical; Reviewed predictionAdd
BLAST
Transmembranei201 – 22121Helical; Reviewed predictionAdd
BLAST
Transmembranei228 – 24821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Undecaprenyl-diphosphataseUniRule annotationPRO_1000197417Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_444.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiPIVFDIY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
SUPFAMiSSF118215. SSF118215. 1 hit.

Sequencei

Sequence statusi: Complete.

B7IFS1-1 [UniParc]FASTAAdd to Basket

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MNHIVLGLIQ GLTEFLPISS SGHLTLFSYL FNIEPNISNF AFLHLATLAA    50
IIVFVWKEIV EILKGLFTLK KEYYSLVLKI IISTIPAAIF GFLFNSTIEN 100
SFSNLKIISF FFLVTAASLF VSDKLKGKKD FFNISYIDAL IIGLFQMIAI 150
FPGISRSGIT LFGALTVGLE REKALKYSFL MGIPVILGAG ILETSKIELN 200
SYILISGLVA FLSGLLSLLI LKKLTISKKL KIFSYYCILI AIIAFFVG 248
Length:248
Mass (Da):27,461
Last modified:February 10, 2009 - v1
Checksum:i86BCDDF5DA29A534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ74935.1.
RefSeqiWP_012579584.1. NC_011653.1.
YP_002334276.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ74935; ACJ74935; THA_444.
GeneIDi7070698.
KEGGitaf:THA_444.
PATRICi23917824. VBITheAfr129358_0444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ74935.1 .
RefSeqi WP_012579584.1. NC_011653.1.
YP_002334276.1. NC_011653.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484019.THA_444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ74935 ; ACJ74935 ; THA_444 .
GeneIDi 7070698.
KEGGi taf:THA_444.
PATRICi 23917824. VBITheAfr129358_0444.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi PIVFDIY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci TAFR484019:GJOH-452-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR001991. Na-dicarboxylate_symporter.
IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
SUPFAMi SSF118215. SSF118215. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
    Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
    J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCF52B.

Entry informationi

Entry nameiUPPP_THEAB
AccessioniPrimary (citable) accession number: B7IFS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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