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B7IFM5 (KPRS_THEAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Ordered Locus Names:THA_396
OrganismThermosipho africanus (strain TCF52B) [Complete proteome] [HAMAP]
Taxonomic identifier484019 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermosipho ›

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00583

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00583.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
PRO_1000212141

Regions

Region217 – 230145-phosphoribose 1-diphosphate binding Potential

Sites

Metal binding1321Magnesium Potential
Metal binding1341Magnesium Potential
Metal binding1431Magnesium Potential
Metal binding1471Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
B7IFM5 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 1480E87A45F99B01

FASTA31634,785
        10         20         30         40         50         60 
MQIAKNEMKI FSGNANRELA IKVSEYIGTR LADCEVGRFA DGEINVKIGE TVRGHDTFII 

        70         80         90        100        110        120 
QPTCPPVNEN LMELLIMIDA LKRASANSIA VVIPYYGYAR QDRKAKGRDP ITAKLVANLL 

       130        140        150        160        170        180 
TVAGATRVMT VDLHSEQIQG FFDIPLDNLW SFPIFAKKLK EDKIVDDDYV IVSPDVGGVK 

       190        200        210        220        230        240 
RARQFAERLG GPLAILDKRR PKDNVAEILN IIGEVEGKTA IIVDDIADTA RSLVNAAKAI 

       250        260        270        280        290        300 
KEKGAKRVIA CITHPVLSDG AIERIQNSEI EKIYISDSIS HSNLPDKFSV VSLAPLLGEA 

       310 
IVRVRKNLSI SILFRQ

« Hide

References

[1]"The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TCF52B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001185 Genomic DNA. Translation: ACJ74889.1.
RefSeqYP_002334230.1. NC_011653.1.

3D structure databases

ProteinModelPortalB7IFM5.
ModBaseSearch...

Protein-protein interaction databases

STRING484019.THA_396.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ74889; ACJ74889; THA_396.
GeneID7070650.
KEGGtaf:THA_396.
PATRIC23917728. VBITheAfr129358_0398.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAYVQIQES.
ProtClustDBPRK01259.

Enzyme and pathway databases

BioCycTAFR484019:GJOH-404-MONOMER.
UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_THEAB
AccessionPrimary (citable) accession number: B7IFM5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: February 10, 2009
Last modified: May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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