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B7IF24

- GCSPB_THEAB

UniProt

B7IF24 - GCSPB_THEAB

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciTAFR484019:GJOH-188-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:THA_183
    OrganismiThermosipho africanus (strain TCF52B)
    Taxonomic identifieri484019 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000002453: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi484019.THA_183.

    Structurei

    3D structure databases

    ProteinModelPortaliB7IF24.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiIFERRIK.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7IF24-1 [UniParc]FASTAAdd to Basket

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    MTIFEISKEG RIGFQLPDNN IKDYEINLPE HLLRKSLPRL PQVSEVDVVR    50
    HYTNLSAKNY SVDVGFYPLG SCTMKYNPKV NEKVASFEEF SMIHPFQPHE 100
    TVQGALKLMY DLKEMLCEIT GMDDMTLIPS AGAHGELTGI LISRAYHLSR 150
    GDTKRTKVIV PDSAHGTNPA SARMAGFDVI EIKSGPDGRV DLNELEKVLD 200
    ETVAVIMLTN PNTLGLFEKD ILKIAQMAHD KGALLYYDGA NLNAILGRTR 250
    PGDMGFDIVH LNLHKTFSTP HGMGGPGSGP VGVKKHLAKF LPVPEIVKIE 300
    DKYTLNYNKP ESIGFIRSYF GNFSVMVRAY TYIKTMGKDG LKKAGEMAVL 350
    NANYLRVKVS KIMDIAYPGI CMHEFVSTCE KLTKETGVKA LDIAKRLLDY 400
    GIHAPTMYFP LIVHEDFMIE PTETESKDTL DKFAQILEKI FNEARENPEL 450
    VKGAPYNTPV RRLDDVSASR KPVFKYNFEE 480
    Length:480
    Mass (Da):53,775
    Last modified:February 10, 2009 - v1
    Checksum:i7EF963D14E1D6A11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ74688.1.
    RefSeqiYP_002334029.1. NC_011653.1.

    Genome annotation databases

    EnsemblBacteriaiACJ74688; ACJ74688; THA_183.
    GeneIDi7070278.
    KEGGitaf:THA_183.
    PATRICi23917290. VBITheAfr129358_0189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ74688.1 .
    RefSeqi YP_002334029.1. NC_011653.1.

    3D structure databases

    ProteinModelPortali B7IF24.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484019.THA_183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ74688 ; ACJ74688 ; THA_183 .
    GeneIDi 7070278.
    KEGGi taf:THA_183.
    PATRICi 23917290. VBITheAfr129358_0189.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi IFERRIK.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci TAFR484019:GJOH-188-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
      Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
      J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCF52B.

    Entry informationi

    Entry nameiGCSPB_THEAB
    AccessioniPrimary (citable) accession number: B7IF24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3