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B7IF24

- GCSPB_THEAB

UniProt

B7IF24 - GCSPB_THEAB

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-188-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:THA_183
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000002453: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132505Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi484019.THA_183.

Structurei

3D structure databases

ProteinModelPortaliB7IF24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiIFERRIK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B7IF24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIFEISKEG RIGFQLPDNN IKDYEINLPE HLLRKSLPRL PQVSEVDVVR
60 70 80 90 100
HYTNLSAKNY SVDVGFYPLG SCTMKYNPKV NEKVASFEEF SMIHPFQPHE
110 120 130 140 150
TVQGALKLMY DLKEMLCEIT GMDDMTLIPS AGAHGELTGI LISRAYHLSR
160 170 180 190 200
GDTKRTKVIV PDSAHGTNPA SARMAGFDVI EIKSGPDGRV DLNELEKVLD
210 220 230 240 250
ETVAVIMLTN PNTLGLFEKD ILKIAQMAHD KGALLYYDGA NLNAILGRTR
260 270 280 290 300
PGDMGFDIVH LNLHKTFSTP HGMGGPGSGP VGVKKHLAKF LPVPEIVKIE
310 320 330 340 350
DKYTLNYNKP ESIGFIRSYF GNFSVMVRAY TYIKTMGKDG LKKAGEMAVL
360 370 380 390 400
NANYLRVKVS KIMDIAYPGI CMHEFVSTCE KLTKETGVKA LDIAKRLLDY
410 420 430 440 450
GIHAPTMYFP LIVHEDFMIE PTETESKDTL DKFAQILEKI FNEARENPEL
460 470 480
VKGAPYNTPV RRLDDVSASR KPVFKYNFEE
Length:480
Mass (Da):53,775
Last modified:February 10, 2009 - v1
Checksum:i7EF963D14E1D6A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ74688.1.
RefSeqiYP_002334029.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ74688; ACJ74688; THA_183.
GeneIDi7070278.
KEGGitaf:THA_183.
PATRICi23917290. VBITheAfr129358_0189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ74688.1 .
RefSeqi YP_002334029.1. NC_011653.1.

3D structure databases

ProteinModelPortali B7IF24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484019.THA_183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ74688 ; ACJ74688 ; THA_183 .
GeneIDi 7070278.
KEGGi taf:THA_183.
PATRICi 23917290. VBITheAfr129358_0189.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi IFERRIK.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TAFR484019:GJOH-188-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
    Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
    J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCF52B.

Entry informationi

Entry nameiGCSPB_THEAB
AccessioniPrimary (citable) accession number: B7IF24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3