B7IF22 (B7IF22_THEAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase RuleBase RU003981
EC=2.1.2.10 RuleBase RU003981

Gene names

Name:	gcvT EMBL ACJ74686.1
Ordered Locus Names:	THA_181

Organism

Thermosipho africanus (strain TCF52B) [Complete proteome] [HAMAP]

Taxonomic identifier

484019 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermosipho

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. RuleBase RU003981 SAAS SAAS022903
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. RuleBase RU003981 SAAS SAAS022903
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. RuleBase RU003981 SAAS SAAS022903
Sequence similarities	Belongs to the GcvT family. RuleBase RU003980

Ontologies

Keywords
Molecular function	Aminotransferase RuleBase RU003981 SAAS SAAS022903 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7IF22 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 6FD44B09FFAA278A	FASTA	436	49,186
	10 20 30 40 50 60 MWKKLLEVDG EINARLIEGM LKTNNIDCVI KSADEPFPKA YFGSTSFFEI YVPKDLFDEA 70 80 90 100 110 120 NNLLNSFKKE ELYMKYTPLY EQHVKLGAKM VEFAGFQMPI QYTGIKDEVI AVRKDVGMFD 130 140 150 160 170 180 VSHMGQVLVE GKDSTNFVNY LITNDFKNLS NGEIVYTAMC NENGGFIDDL LAYKISDEKA 190 200 210 220 230 240 FLVINAANIE KDFEWMKNVA LNFDVKLENK SDDYALIAIQ GPNAQKTLQK LTDIDLESIG 250 260 270 280 290 300 YYTFVFGKVK DVEALISRTG YTGEDGFEIY TTDKDGIVKI WEELLNLGVK PAGLGARDTL 310 320 330 340 350 360 RLEASLLLYG NDMDETVTPL EAGIKWAVKF DKEFVGKAAL EKQLEEGLKR RLKGFKLIDK 370 380 390 400 410 420 GIARHGYKVF KDGREIGVVT SGTFSPTLDE SIGMALIETG YKSGDIIEIE IRNKLVKAEI 430 VKMPFYRGSV RSKKKK

References

[1]

"The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea." Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F. J. Bacteriol. 191:1974-1978(2009) [PubMed: 19124572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001185 Genomic DNA. Translation: ACJ74686.1.
RefSeq	YP_002334027.1. NC_011653.1.
3D structure databases
ProteinModelPortal	B7IF22.
ModBase	Search...
Protein-protein interaction databases
STRING	B7IF22.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7070276.
GenomeReviews	Gene locus THA_181 in contig CP001185_GR.
KEGG	taf:THA_181.
PATRIC	23917286. VBITheAfr129358_0187.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B7IF22_THEAB

Accession

Primary (citable) accession number: B7IF22

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)