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Protein

Adenine deaminase

Gene

ade

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Adenine + H2O = hypoxanthine + NH3.UniRule annotation

Cofactori

Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-30-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine deaminaseUniRule annotation (EC:3.5.4.2UniRule annotation)
Short name:
AdenaseUniRule annotation
Short name:
Adenine aminaseUniRule annotation
Gene namesi
Name:adeUniRule annotation
Ordered Locus Names:THA_28
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeThermosipho
Proteomesi
  • UP000002453 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Adenine deaminasePRO_1000146246Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_28.

Structurei

3D structure databases

ProteinModelPortaliB7IEM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenine deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPN. Bacteria.
COG1001. LUCA.
HOGENOMiHOG000276949.
KOiK01486.
OMAiCTDDKHL.
OrthoDBiPOG091H00I8.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01518. Adenine_deamin. 1 hit.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01178. ade. 1 hit.

Sequencei

Sequence statusi: Complete.

B7IEM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYEIVPVA LGKKMPDVLI KNVNLVNVFT GKIEKTNIAL YKKRIAGIGD
60 70 80 90 100
DYKVGKEVID AKGLFAIPGL IDAHVHIESS MLSPTEFAKL ILPFGTTTII
110 120 130 140 150
ADPHEIANVL GVEGIEYMIK STEGIPLNVY FAIPSAVPAT NLETSGATLG
160 170 180 190 200
AEDMVSLVEK YPFRIIALGE VMNYPGVLDC DRDLITKIEI LRHKYKKIDG
210 220 230 240 250
HAPGLTGKEL NAYIDAFVRS DHECETKEEA LEKLSKGMQI FIREGTAARN
260 270 280 290 300
LNALLPAVNE MNHFFFSFCT DDRDPNDIIE RGHINGIIKS AIDSGIDPII
310 320 330 340 350
AIRMATINTA KYFNLRSMGA ISPGYKADIV FIDNLKDFNI KFVIKDSKIV
360 370 380 390 400
VEDKRINMNV ESIIRNIPNT LGKINIVKNY SLSIKNRNRK IRVISVKSGT
410 420 430 440 450
LLTDELIVEP NVEKGYVVSD IDRDIIKIAV FDRHKASGYS IGFVHGLSIK
460 470 480 490 500
NGAVATTIGH DSHNLTVVGT NDEDMNYAIS RIKELNGGIV VVKNKKLIAS
510 520 530 540 550
LSLPIAGLMS DKNYGFVVEE LRKLKNSLVE IGVNSDILMQ IHFLQLAVIP
560 570
KLKITDKGLI DVEKQKIVDL FVEV
Length:574
Mass (Da):63,466
Last modified:February 10, 2009 - v1
Checksum:iB9147A1E7B1C8F42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ74536.1.
RefSeqiWP_004103343.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ74536; ACJ74536; THA_28.
KEGGitaf:THA_28.
PATRICi23916970. VBITheAfr129358_0030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ74536.1.
RefSeqiWP_004103343.1. NC_011653.1.

3D structure databases

ProteinModelPortaliB7IEM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi484019.THA_28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ74536; ACJ74536; THA_28.
KEGGitaf:THA_28.
PATRICi23916970. VBITheAfr129358_0030.

Phylogenomic databases

eggNOGiENOG4105CPN. Bacteria.
COG1001. LUCA.
HOGENOMiHOG000276949.
KOiK01486.
OMAiCTDDKHL.
OrthoDBiPOG091H00I8.

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-30-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_01518. Adenine_deamin. 1 hit.
InterProiIPR006679. Adenine_deam.
IPR026912. Adenine_deam_C.
IPR006680. Amidohydro-rel.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF13382. Adenine_deam_C. 1 hit.
PF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01178. ade. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADEC_THEAB
AccessioniPrimary (citable) accession number: B7IEM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.