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B7IEE2

- PCP_THEAB

UniProt

B7IEE2 - PCP_THEAB

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Protein
Pyrrolidone-carboxylate peptidase
Gene
pcp, THA_1947
Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei78 – 781 By similarity
Active sitei141 – 1411 By similarity
Active sitei165 – 1651 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. pyroglutamyl-peptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciTAFR484019:GJOH-1987-MONOMER.

    Protein family/group databases

    MEROPSiC15.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyrrolidone-carboxylate peptidase (EC:3.4.19.3)
    Alternative name(s):
    5-oxoprolyl-peptidase
    Pyroglutamyl-peptidase I
    Short name:
    PGP-I
    Short name:
    Pyrase
    Gene namesi
    Name:pcp
    Ordered Locus Names:THA_1947
    OrganismiThermosipho africanus (strain TCF52B)
    Taxonomic identifieri484019 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000002453: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Pyrrolidone-carboxylate peptidaseUniRule annotation
    PRO_1000124004Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi484019.THA_1947.

    Structurei

    3D structure databases

    ProteinModelPortaliB7IEE2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C15 family.

    Phylogenomic databases

    eggNOGiCOG2039.
    HOGENOMiHOG000242641.
    KOiK01304.
    OMAiNDGENAY.
    OrthoDBiEOG6X1124.

    Family and domain databases

    Gene3Di3.40.630.20. 1 hit.
    HAMAPiMF_00417. Pyrrolid_peptidase.
    InterProiIPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view]
    PANTHERiPTHR23402. PTHR23402. 1 hit.
    PfamiPF01470. Peptidase_C15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSiPR00706. PYROGLUPTASE.
    PROSITEiPS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7IEE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILITGFEP FGGEVVNPSF EAVKHLPDSI EKAQIVKAAI HTVFRKSIEV    50
    LEELIVKEKP DIVICVGQAG GRAEITIERV AINIDDAKNP DNEGNTPKDE 100
    VIFEDGENAY FSNLPIKKMV EEIKNCKIPA SISNSAGTYV CNHLMYGLLY 150
    LINKKYKNMK GGFIHVPYLP QQVLNKKNVP SMSLDNIVQA LVCSIKAILK 200
    EYNDE 205
    Length:205
    Mass (Da):22,818
    Last modified:February 10, 2009 - v1
    Checksum:i3D6E8BC7E2F10FD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ76369.1.
    RefSeqiYP_002335710.1. NC_011653.1.

    Genome annotation databases

    EnsemblBacteriaiACJ76369; ACJ76369; THA_1947.
    GeneIDi7071033.
    KEGGitaf:THA_1947.
    PATRICi23920964. VBITheAfr129358_1972.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001185 Genomic DNA. Translation: ACJ76369.1 .
    RefSeqi YP_002335710.1. NC_011653.1.

    3D structure databases

    ProteinModelPortali B7IEE2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 484019.THA_1947.

    Protein family/group databases

    MEROPSi C15.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ76369 ; ACJ76369 ; THA_1947 .
    GeneIDi 7071033.
    KEGGi taf:THA_1947.
    PATRICi 23920964. VBITheAfr129358_1972.

    Phylogenomic databases

    eggNOGi COG2039.
    HOGENOMi HOG000242641.
    KOi K01304.
    OMAi NDGENAY.
    OrthoDBi EOG6X1124.

    Enzyme and pathway databases

    BioCyci TAFR484019:GJOH-1987-MONOMER.

    Family and domain databases

    Gene3Di 3.40.630.20. 1 hit.
    HAMAPi MF_00417. Pyrrolid_peptidase.
    InterProi IPR000816. Peptidase_C15.
    IPR016125. Peptidase_C15-like.
    [Graphical view ]
    PANTHERi PTHR23402. PTHR23402. 1 hit.
    Pfami PF01470. Peptidase_C15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015592. Prld-crbxl_pptds. 1 hit.
    PRINTSi PR00706. PYROGLUPTASE.
    PROSITEi PS01334. PYRASE_CYS. 1 hit.
    PS01333. PYRASE_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
      Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
      J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TCF52B.

    Entry informationi

    Entry nameiPCP_THEAB
    AccessioniPrimary (citable) accession number: B7IEE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: September 3, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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