B7IE73 (PPNK_THEAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	THA_1874

Organism

Thermosipho africanus (strain TCF52B) [Complete proteome] [HAMAP]

Taxonomic identifier

484019 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermosipho › Thermosipho africanus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD metabolic process Inferred from electronic annotation. Source: InterPro NADP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361		PRO_1000120892

Sequences

	Sequence		Length	Mass (Da)
	B7IE73 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: E126E15FB5B6751A	FASTA	255	28,513
	10 20 30 40 50 60 MKHLGIFYKP ELFGKAESLK ELLLNEGYIV DYCESSERIK NNKVDLTIVL GGDGTFLKAS 70 80 90 100 110 120 HLVNNPLVGF KGGRLGFLSS YTVEEFDKFL KDLKNNNFVS DERTFLKVSD LNTFCLNEVL 130 140 150 160 170 180 LVKDPDQKMV DIKISFQDGE LFFHADGIML STPTGSTGYS LSLGGPILLP NTKAFVITPV 190 200 210 220 230 240 APQFLASRSI VIPDNEKVNI EVDKRVNLII DGVNFGKFSK ITVMKSKKKI SILRPVDYDF 250 TKSIKEKLGY GKKIL

References

[1]

"The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea." Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F. J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TCF52B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001185 Genomic DNA. Translation: ACJ76300.1.
RefSeq	YP_002335641.1. NC_011653.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	484019.THA_1874.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ76300; ACJ76300; THA_1874.
GeneID	7070380.
KEGG	taf:THA_1874.
PATRIC	23920806. VBITheAfr129358_1894.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HOG000227222.
KO	K00858.
OMA	FPRENFL.
ProtClustDB	PRK14075.
Family and domain databases
Gene3D	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAP	MF_00361. NAD_kinase.
InterPro	IPR017438. ATP-NAD_kinase_dom_1. IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. PolyP/ATP_NADK_prd. [Graphical view]
PANTHER	PTHR20275. PTHR20275. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_THEAB

Accession

Primary (citable) accession number: B7IE73

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program