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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi492MagnesiumUniRule annotation1
Metal bindingi498MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:THA_1819
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeThermosipho
Proteomesi
  • UP000002453 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003819251 – 697Polyribonucleotide nucleotidyltransferaseAdd BLAST697

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_1819.

Structurei

3D structure databases

ProteinModelPortaliB7IE23.
SMRiB7IE23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 619KHUniRule annotationAdd BLAST61
Domaini629 – 696S1 motifUniRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QUF. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRYMHNYN.
OrthoDBiPOG091H00M0.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiView protein in InterPro
IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR036345. ExoRNase_PH_dom2_sf.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR036612. KH_dom_type_1_sf.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom_sf.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR036456. PNPase_PH_RNA-bd_sf.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiView protein in Pfam
PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiView protein in SMART
SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiView protein in PROSITE
PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.

Sequencei

Sequence statusi: Complete.

B7IE23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFREWTKEL FGRKMIVQHG KVAKQSAGSV WVQFGDSVVL ATANISDRTI
60 70 80 90 100
EGVDFVPLTV EYQEKFYAAG KIPGGFIKRE GKPSESAILS ARLIDRPIRP
110 120 130 140 150
LFPKYLRNDV QLIVTVLSVD GNTPPDVTGI IAASLALNIS KIPFEGIVAG
160 170 180 190 200
VRLGYVDGKF VVFPTEEQLE KSRLDIVVAG SKDAITMVEG EAKEVTEEEM
210 220 230 240 250
VNALMVAHDA IKQIIEFEEE ILSQFDVQKM EIEEPKPNET LIGKFEEMIS
260 270 280 290 300
EEELRDKLLI KEKLERSAKL KEYRDQILEK IFEDVEMEDD EKILQESLLK
310 320 330 340 350
EYFDERTKKL MRKIIIEEGI RADGRKVDEI RPITCEVGVL PRTHGSALFT
360 370 380 390 400
RGETQSLGIV TLGAPMEEQI VDTIMEEGTK RFILHYNFPP FSVGEVKPLR
410 420 430 440 450
GPGRREIGHG HLAERALKAV VPSEEEFPYV VRVVSEILES NGSSSMATVC
460 470 480 490 500
SGSLALMDAG VPIRTHVAGV AMGLIIEDGQ EVVLTDIQGL EDHWGDMDFK
510 520 530 540 550
VAGTRNGITA FQMDCKVAGV GEELLKRALQ QAKEARMKIL DIMFNTIEKP
560 570 580 590 600
RESLSPYAPL IVTIEIDPMK VGELIGPGGK VIKSIIKEYD VEISIDDTTG
610 620 630 640 650
KVSIYGKDQK KVNEAIEYIK TITKDIEVGD VFEGKITRIE PYGIFVELMP
660 670 680 690
GKIGLAHSSK LGEDSKNFKE KYKIGDTIKV IVVNIDENGR IQLGKTN
Length:697
Mass (Da):77,669
Last modified:February 10, 2009 - v1
Checksum:i2FD460DC02486705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001185 Genomic DNA. Translation: ACJ76250.1.
RefSeqiWP_012580442.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ76250; ACJ76250; THA_1819.
KEGGitaf:THA_1819.

Similar proteinsi

Entry informationi

Entry nameiPNP_THEAB
AccessioniPrimary (citable) accession number: B7IE23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: February 10, 2009
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families