Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7ICT4

- GCH4_THEAB

UniProt

B7ICT4 - GCH4_THEAB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermosipho africanus (strain TCF52B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-1400-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:THA_1366
OrganismiThermosipho africanus (strain TCF52B)
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000002453: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259GTP cyclohydrolase FolE2PRO_1000185158Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_1366.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiLIWFEDL.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

B7ICT4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDVQSERDE RNVPLKHVGI KNLKYPVVVL DKKNKNQHTI AEINMYVDLP
60 70 80 90 100
KDFRGTHMSR FLEVLNKFHL KIDPKNIKAI LDDLKKTLKA QSASIEIMFP
110 120 130 140 150
YFLQKKAPVT KIESYMEYKC GFKAYDTNEE CEFYIVVEVP IQTLCPCSKE
160 170 180 190 200
ISKYNAHNQR ALARIEVETS ELIWFEDLIE LAESSASVPL FTLLKRPDEK
210 220 230 240 250
YVTEKAYENP KFVEDVARDI ALSLKENKKI RWFKVEVESF ESIHNHNAYA

CVNSDTMEV
Length:259
Mass (Da):30,260
Last modified:February 10, 2009 - v1
Checksum:i91B935EF72AAC080
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75811.1.
RefSeqiYP_002335152.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ75811; ACJ75811; THA_1366.
GeneIDi7070535.
KEGGitaf:THA_1366.
PATRICi23919751. VBITheAfr129358_1379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75811.1 .
RefSeqi YP_002335152.1. NC_011653.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484019.THA_1366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ75811 ; ACJ75811 ; THA_1366 .
GeneIDi 7070535.
KEGGi taf:THA_1366.
PATRICi 23919751. VBITheAfr129358_1379.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi LIWFEDL.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci TAFR484019:GJOH-1400-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
    Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
    J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCF52B.

Entry informationi

Entry nameiGCH4_THEAB
AccessioniPrimary (citable) accession number: B7ICT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3