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B7ICM4

- B7ICM4_THEAB

UniProt

B7ICM4 - B7ICM4_THEAB

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Protein

Alanine racemase

Gene

THA_1306

Organism
Thermosipho africanus (strain TCF52B)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Active sitei255 – 2551Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-1340-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:THA_1306Imported
OrganismiThermosipho africanus (strain TCF52B)Imported
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000002453: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_1306.

Structurei

3D structure databases

ProteinModelPortaliB7ICM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiAEININN.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ICM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTESRRTFA EININNYIEN LKYFQKKCSP AKVMPVIKAN AYGHGAVMLA
60 70 80 90 100
KSAEKMGIDY FAVAFLEEAL ILRKNGINTN ILVFNYLDKD FVPLAADNNI
110 120 130 140 150
TITIISNEQV EEYKDLIKKP KVHINIDTGM NRVGIEPKDA MKIYEKLISN
160 170 180 190 200
GFEVEGIYTH FAVADSLKKE DIEFTKKQYE KFLEVNLPVK IRHTNNSAAS
210 220 230 240 250
LSGIISCGDY VRIGIASYGL MPSNQVKDEN LKPVLTWKSV VSHVKTLKKG
260 270 280 290 300
ESVSYGRTFV APYDMKVATI PVGYADGYWR HLSNNGEVLI NGKRRKILGR
310 320 330 340 350
VCMDQFVVEA DDEVKIGDEV ILIGKQGNEF ISAEEIADKV GTINYEVTCR
360
ISERVPRIYK GVEL
Length:364
Mass (Da):40,923
Last modified:February 10, 2009 - v1
Checksum:i6C17BA6F3E725F2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75751.1.
RefSeqiYP_002335092.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ75751; ACJ75751; THA_1306.
GeneIDi7071972.
KEGGitaf:THA_1306.
PATRICi23919629. VBITheAfr129358_1318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75751.1 .
RefSeqi YP_002335092.1. NC_011653.1.

3D structure databases

ProteinModelPortali B7ICM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484019.THA_1306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ75751 ; ACJ75751 ; THA_1306 .
GeneIDi 7071972.
KEGGi taf:THA_1306.
PATRICi 23919629. VBITheAfr129358_1318.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi AEININN.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TAFR484019:GJOH-1340-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
    Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.
    J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCF52BImported.

Entry informationi

Entry nameiB7ICM4_THEAB
AccessioniPrimary (citable) accession number: B7ICM4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3