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B7ICM4

- B7ICM4_THEAB

UniProt

B7ICM4 - B7ICM4_THEAB

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Protein

Alanine racemase

Gene
THA_1306
Organism
Thermosipho africanus (strain TCF52B)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Active sitei255 – 2551Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei303 – 3031Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciTAFR484019:GJOH-1340-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:THA_1306Imported
OrganismiThermosipho africanus (strain TCF52B)Imported
Taxonomic identifieri484019 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000002453: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi484019.THA_1306.

Structurei

3D structure databases

ProteinModelPortaliB7ICM4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiAEININN.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ICM4-1 [UniParc]FASTAAdd to Basket

« Hide

MGTESRRTFA EININNYIEN LKYFQKKCSP AKVMPVIKAN AYGHGAVMLA    50
KSAEKMGIDY FAVAFLEEAL ILRKNGINTN ILVFNYLDKD FVPLAADNNI 100
TITIISNEQV EEYKDLIKKP KVHINIDTGM NRVGIEPKDA MKIYEKLISN 150
GFEVEGIYTH FAVADSLKKE DIEFTKKQYE KFLEVNLPVK IRHTNNSAAS 200
LSGIISCGDY VRIGIASYGL MPSNQVKDEN LKPVLTWKSV VSHVKTLKKG 250
ESVSYGRTFV APYDMKVATI PVGYADGYWR HLSNNGEVLI NGKRRKILGR 300
VCMDQFVVEA DDEVKIGDEV ILIGKQGNEF ISAEEIADKV GTINYEVTCR 350
ISERVPRIYK GVEL 364
Length:364
Mass (Da):40,923
Last modified:February 10, 2009 - v1
Checksum:i6C17BA6F3E725F2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75751.1.
RefSeqiYP_002335092.1. NC_011653.1.

Genome annotation databases

EnsemblBacteriaiACJ75751; ACJ75751; THA_1306.
GeneIDi7071972.
KEGGitaf:THA_1306.
PATRICi23919629. VBITheAfr129358_1318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001185 Genomic DNA. Translation: ACJ75751.1 .
RefSeqi YP_002335092.1. NC_011653.1.

3D structure databases

ProteinModelPortali B7ICM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484019.THA_1306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ75751 ; ACJ75751 ; THA_1306 .
GeneIDi 7071972.
KEGGi taf:THA_1306.
PATRICi 23919629. VBITheAfr129358_1318.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi AEININN.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci TAFR484019:GJOH-1340-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Thermosipho africanus TCF52B: lateral genetic connections to the Firmicutes and Archaea."
    Nesbo C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D., Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.K., Doolittle W.F.
    J. Bacteriol. 191:1974-1978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TCF52BImported.

Entry informationi

Entry nameiB7ICM4_THEAB
AccessioniPrimary (citable) accession number: B7ICM4
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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