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B7ICE9 (PYRE_ACIB5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:AB57_3791
OrganismAcinetobacter baumannii (strain AB0057) [Complete proteome] [HAMAP]
Taxonomic identifier480119 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_1000138754

Regions

Region38 – 392Orotate binding By similarity
Region75 – 7625-phosphoribose 1-diphosphate binding By similarity
Region128 – 13695-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site3015-phosphoribose 1-diphosphate By similarity
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10315-phosphoribose 1-diphosphate By similarity
Binding site10615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1321Orotate By similarity
Binding site1601Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
B7ICE9 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 654166B5CB773CF9

FASTA21623,349
        10         20         30         40         50         60 
MTTPVSFHPQ AFIELALSRG VLKFGEFTLK SGRVSPYFFN AGLLNDGEAL SLLAQGYADK 

        70         80         90        100        110        120 
LTQCENVDVI FGPAYKGIPF VAATAVALSQ THNKSVPWGF NRKEAKDHGE GGILVGAAVE 

       130        140        150        160        170        180 
GKKVWIIDDV ITAGTAIREV VTILKNAGAT IAGVLVALDR QERGQGELSA IQEVQKELEI 

       190        200        210 
PVHALITMKD LMDYLEAKGE KEALANMQAY REKYGI

« Hide

References

[1]"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii."
Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R.
J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB0057.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001182 Genomic DNA. Translation: ACJ43143.1.
RefSeqYP_002321079.1. NC_011586.1.

3D structure databases

ProteinModelPortalB7ICE9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7ICE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7043772.
GenomeReviewsGene locus AB57_3791 in contig CP001182_GR.
KEGGabn:AB57_3791.
PATRIC20701268. VBIAciBau111166_3645.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMAFAFNRKE.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_ACIB5
AccessionPrimary (citable) accession number: B7ICE9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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