Skip Header

Contribute Send feedback
Read comments (?) or add your own

B7IAW6 (MRAY_ACIB5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:AB57_3652
OrganismAcinetobacter baumannii (strain AB0057) [Complete proteome] [HAMAP]
Taxonomic identifier480119 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000116500

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane211 – 23121Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane275 – 29521Helical; Potential
Transmembrane300 – 32021Helical; Potential
Transmembrane349 – 36921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B7IAW6 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 3CBE5DE5B81B67F0

FASTA37240,915
        10         20         30         40         50         60 
MLLWLFEQLA GYHSSFQVVR YLTLRSLLSV LTSLTIGLVL GPIMIRKLQA LKYGQAVSSF 

        70         80         90        100        110        120 
APENHAKKMG TPTMGGILIL LSIGISTLLW ADLSNPYVWI VLGVMVVFGA VGWADDWIKI 

       130        140        150        160        170        180 
RYKDNAGLPA RKKFFWTSVA SLGAGIALYL IATQQSNAEY TANMLDLLIP FFKNLSIPLS 

       190        200        210        220        230        240 
IVPLGLAFIV FTYLVINGAS NAVNLTDGLD GLAIMPVVMV ATGLGVFAYL SGDIRFANYL 

       250        260        270        280        290        300 
HIPYVKYTSE LVVICSAMIG AGLAFLWYNA HPAQVFMGDV GALALGAMLG TIAVMVRQEI 

       310        320        330        340        350        360 
VFAIMGGVFV MEAVSVFLQI GSLRMRNKRV FLMAPLHHHY EKQGWKETQV VIRFWIITIM 

       370 
LVVLGLMTLK LR

« Hide

References

[1]"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii."
Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R.
J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB0057.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001182 Genomic DNA. Translation: ACJ43013.1.
RefSeqYP_002320949.1. NC_011586.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB7IAW6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7044603.
GenomeReviewsGene locus AB57_3652 in contig CP001182_GR.
KEGGabn:AB57_3652.
PATRIC20700983. VBIAciBau111166_3511.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMAAGGLMFY.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACIB5
AccessionPrimary (citable) accession number: B7IAW6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents