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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

AB57_1185

Organism
Acinetobacter baumannii (strain AB0057)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (AB57_1185)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciABAU480119:GHQY-1196-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:AB57_1185
OrganismiAcinetobacter baumannii (strain AB0057)
Taxonomic identifieri480119 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Probable 5-dehydro-4-deoxyglucarate dehydratasePRO_1000132265Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB7I9K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

B7I9K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDALELKNII SDGLLSFPVT DFDQNGDFNK SSYAKRLEWL APYGASALFA
60 70 80 90 100
AGGTGEFFSL TGNEYSEVIK TAVDTCRGSV PIIAGAGGPT RQAIEQAKEA
110 120 130 140 150
ERLGAHGILL MPHYLTEASQ EGLIEHVKQV CNSVDFGVIF YNRSVSRLNL
160 170 180 190 200
DSIQKLTEMC PNLIGFKDSS GQIDMMTAVT QTMGDRLSYL GGLPTAEVFA
210 220 230 240 250
APYKALGCPV YSSAVFNFIP KTAMEFYNAL RSDDFETTNR LIKDFFLPLI
260 270 280 290 300
KIRDRKSGYA VSMIKAGAKI VGHDAGPVRP PLSDLTQADY EDLAALIATL

GPQ
Length:303
Mass (Da):32,859
Last modified:February 10, 2009 - v1
Checksum:i203E1CAD981819CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001182 Genomic DNA. Translation: ACJ40208.1.
RefSeqiWP_000339256.1. NC_011586.1.

Genome annotation databases

EnsemblBacteriaiACJ40208; ACJ40208; AB57_1185.
KEGGiabn:AB57_1185.
PATRICi20696184. VBIAciBau111166_1158.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001182 Genomic DNA. Translation: ACJ40208.1.
RefSeqiWP_000339256.1. NC_011586.1.

3D structure databases

ProteinModelPortaliB7I9K0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ40208; ACJ40208; AB57_1185.
KEGGiabn:AB57_1185.
PATRICi20696184. VBIAciBau111166_1158.

Phylogenomic databases

HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciABAU480119:GHQY-1196-MONOMER.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDGD_ACIB5
AccessioniPrimary (citable) accession number: B7I9K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.