Reviewed, UniProtKB/Swiss-Prot B7I933 (ARGC_ACIB5)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	AB57_2247

Organism

Acinetobacter baumannii (strain AB0057) [Complete proteome] [HAMAP]

Taxonomic identifier

480119 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000118050
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7I933-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 736F7F41E6C104A2	FASTA	349	38,012
	10 20 30 40 50 60 MISVGIVGGT GYTGVELLRI LLRHPKAQVR VLTSRTEAGK PVADMFPNLR GHTDLQFSDL 70 80 90 100 110 120 NIDALKECDV VFFATPHGVA MQHAKDLIAA GTKVIDLAAD FRLQNLEQFE KWYGMEHACP 130 140 150 160 170 180 DVLKDSVYGL TELNREKIKQ AQVIGNPGCY PTTVQLGLAP LLKSAQALIE TKNIIIDAKS 190 200 210 220 230 240 GVSGAGRKAS LGMIYSENAD NFKAYGVAGH RHHPEIVEAL ENIAGKKDVF EGLLFVPHLV 250 260 270 280 290 300 PMIRGMLSTI YVDLTEAGKQ TALQALYENF YANEKFVDVM PANSSPETRS VRGANELRIA 310 320 330 340 LYKPQPNKLI ILAAQDNLVK GASGQAVQNM NLMFGFNEDE GLQGIGLLP

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001182 Genomic DNA. Translation: ACJ41618.1.
RefSeq	YP_002319601.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7045075.
GenomeReviews	Gene locus AB57_2247 in contig CP001182_GR.
KEGG	abn:AB57_2247.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ACIB5

Accession

Primary (citable) accession number: B7I933

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	June 16, 2009
This is version 6 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)