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B7I624

- PCKG_ACIB5

UniProt

B7I624 - PCKG_ACIB5

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Acinetobacter baumannii (strain AB0057)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
    Metal bindingi225 – 2251ManganeseUniRule annotation
    Binding sitei225 – 2251SubstrateUniRule annotation
    Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei269 – 2691UniRule annotation
    Metal bindingi294 – 2941ManganeseUniRule annotation
    Binding sitei384 – 3841GTPUniRule annotation
    Binding sitei415 – 4151GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi268 – 2736GTPUniRule annotation
    Nucleotide bindingi516 – 5194GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciABAU480119:GHQY-3066-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:AB57_3085
    OrganismiAcinetobacter baumannii (strain AB0057)
    Taxonomic identifieri480119 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000007094: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 610610Phosphoenolpyruvate carboxykinase [GTP]PRO_1000125038Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi480119.AB57_3085.

    Structurei

    3D structure databases

    ProteinModelPortaliB7I624.
    SMRiB7I624. Positions 10-604.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni382 – 3843Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiWDNPAGV.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7I624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTVNAPEFV RHPKLIAWVE EIANLTKPAK IEWCDGSEEE YQRLIDLMIA    50
    NGTMQKLNQE KHPGSYLANS DPSDVARVED RTYICSQNKE DAGATNNWED 100
    PAVMREKLNG LFEGSMKGRT MYVVPFSMGP LGSHIAHIGI ELTDSPYVAV 150
    SMRKMARMGK AVYDVLGTDG EFVPCVHTVG APLAEGQKDV AWPCNPEKYI 200
    VHYPETREIW SFGSGYGGNA LLGKKCLALR IASVMGREQG WLAEHMLILG 250
    VTNPQGEKHY IAAAFPSACG KTNFAMLIPP AGYEGWKIET VGDDIAWIKP 300
    GEDGRLYAIN PEAGFFGVAP GTNTKTNPNC MATLHKDVIY TNVAVTDDGQ 350
    VWWEGLSKEV PANLTNWKGQ PHVNGEKAAH PNARFTVAAG QCPSIDADWE 400
    NPAGVPISAF IFGGRRADTV PLVSEAFDWV DGVYKAATMG SETTAAAVGQ 450
    QGIVRRDPFA MLPFAGYNMA DYFDHWLNLG AKVSEKAEAS GNKLPKIFNV 500
    NWFRRDAEGN FVWPGFGQNM RVLEWIIDRC EGRANAVETP IGFVPTYEDL 550
    NWEGTEFTKE QFDLITNQDR DQWVTEIESH TELFNKLGER LPKALKERQA 600
    ALLEAVKTGF 610
    Length:610
    Mass (Da):67,448
    Last modified:February 10, 2009 - v1
    Checksum:i6FAD9D3231AD796E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001182 Genomic DNA. Translation: ACJ42417.1.
    RefSeqiYP_002320406.1. NC_011586.1.

    Genome annotation databases

    EnsemblBacteriaiACJ42417; ACJ42417; AB57_3085.
    GeneIDi7046546.
    KEGGiabn:AB57_3085.
    PATRICi20699849. VBIAciBau111166_2972.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001182 Genomic DNA. Translation: ACJ42417.1 .
    RefSeqi YP_002320406.1. NC_011586.1.

    3D structure databases

    ProteinModelPortali B7I624.
    SMRi B7I624. Positions 10-604.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 480119.AB57_3085.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ42417 ; ACJ42417 ; AB57_3085 .
    GeneIDi 7046546.
    KEGGi abn:AB57_3085.
    PATRICi 20699849. VBIAciBau111166_2972.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi WDNPAGV.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci ABAU480119:GHQY-3066-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AB0057.

    Entry informationi

    Entry nameiPCKG_ACIB5
    AccessioniPrimary (citable) accession number: B7I624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3