Reviewed, UniProtKB/Swiss-Prot B7I4X1 (NTPA_ACIB5)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

AB57_0572

Organism

Acinetobacter baumannii (strain AB0057) [Complete proteome] [HAMAP]

Taxonomic identifier

480119 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000145477

Sequences

	Sequence		Length	Mass (Da)
	B7I4X1-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: DF44EF7796B74B41	FASTA	208	22,788
	10 20 30 40 50 60 MSTPHWFDQG SLVLASNNKG KVAEFEKLFE QLKLPVEIIP QGRLNIPDAI EDGLSFIENA 70 80 90 100 110 120 IIKARHASKI SGKPAMADDS GICVPVLGGA PGIYSARYAG EHGDDAANNA KLLNDLLPFR 130 140 150 160 170 180 KNGEAIEGMF VCVLALVTHA EDPLPQIFQG IWHGEILEAP RGENGFGYDP LFWLPELQVS 190 200 SAELSKEDKN KISHRGQAMQ LFRESLQK

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001182 Genomic DNA. Translation: ACJ39993.1.
RefSeq	YP_002317976.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7043622.
GenomeReviews	Gene locus AB57_0572 in contig CP001182_GR.
KEGG	abn:AB57_0572.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_ACIB5

Accession

Primary (citable) accession number: B7I4X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	June 16, 2009
This is version 6 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)