true2009-04-142024-03-2769TYSY_ACIB5Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii.Adams M.D.Goglin K.Molyneaux N.Hujer K.M.Lavender H.Jamison J.J.MacDonald I.J.Martin K.M.Russo T.Campagnari A.A.Hujer A.M.Bonomo R.A.Gill S.R.doi:10.1128/jb.00834-082008J. Bacteriol.1908053-8064NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]AB00571.50A/B=1-280TS_Pyrimidine_HMaseThymidylate synthase/dCMP hydroxymethylase domainThymidy_synth_bactThymidate_synth/dCMP_MeaseThymidate_synth/dCMP_Mease_domThymidate_synth/dCMP_Mease_sfThymidylate_synthaseThymidylate_synthase_ASthym_symTHYMIDYLATE SYNTHASETHYMIDYLATE SYNTHASE 1Thymidylat_syntTHYMDSNTHASEThymidylate synthase/dCMP hydroxymethylaseTHYMIDYLATE_SYNTHASEThymidylate synthaseTSTSase2.1.1.45thyAAB57_0541Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.Homodimer.Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.Thymidylate synthase318261280Nucleophile162in other chain2151142143in other chain182185in other chain193in other chain223225279141618232637384049637074818386909193103109118120127137145147151154157159171174186189190207211226228229236244248255257260262263267ligand shared between dimeric partners2009-02-101318264024d8cf677de7863e87da96b4a0a022MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELLWFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTYNQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAKLQLTREPLPLCQLKLNPEVKDIFDFKFEDIEIVGYESHPAIKAPVAVtrue