Reviewed, UniProtKB/Swiss-Prot B7I4U0 (TYSY_ACIB5)

Names and origin

Protein names

Recommended name:
    Thymidylate synthase
      Short name=TS
      Short name=TSase
    EC=2.1.1.45

Gene names

Name:	thyA
Ordered Locus Names:	AB57_0541

Organism

Acinetobacter baumannii (strain AB0057) [Complete proteome] [HAMAP]

Taxonomic identifier

480119 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008
Pathway	Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thymidylate synthase family. Bacterial-type thyA subfamily.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Thymidylate synthase HAMAP MF_00008		PRO_1000197228
Sites
	Active site	162	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7I4U0-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 4BC33ECB88E38F86	FASTA	280	31,826
	10 20 30 40 50 60 MRAYLDLLQH ILDNGGDKGD RTGTGTRSVF GHQMRFDLSK GFPLLTTKKV HFRSIVIELL 70 80 90 100 110 120 WFLKGDTNVK YLQDNKVTIW DEWATAEQTA RFGRPEHELG PVYGHQWRNF GATKNADGTY 130 140 150 160 170 180 NQDGFDQIKW LINEIKTNPN SRRLIVSGWN PNEAGQVALP PCHTLFQFFV QDNKLSCQLY 190 200 210 220 230 240 QRSADVFLGV PFNIASYALL THMIAQVCGL GVGDFVWTGG DTHLYANHFE QAKLQLTREP 250 260 270 280 LPLCQLKLNP EVKDIFDFKF EDIEIVGYES HPAIKAPVAV

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001182 Genomic DNA. Translation: ACJ39962.1.
RefSeq	YP_002317945.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7044962.
GenomeReviews	Gene locus AB57_0541 in contig CP001182_GR.
KEGG	abn:AB57_0541.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00008. [Tree]
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_ACIB5

Accession

Primary (citable) accession number: B7I4U0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	July 28, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)