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B7I4U0

- TYSY_ACIB5

UniProt

B7I4U0 - TYSY_ACIB5

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Protein
Thymidylate synthase
Gene
thyA, AB57_0541
Organism
Acinetobacter baumannii (strain AB0057)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciABAU480119:GHQY-553-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:AB57_0541
OrganismiAcinetobacter baumannii (strain AB0057)
Taxonomic identifieri480119 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000007094: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Thymidylate synthaseUniRule annotation
PRO_1000197228Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi480119.AB57_0541.

Structurei

3D structure databases

ProteinModelPortaliB7I4U0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7I4U0-1 [UniParc]FASTAAdd to Basket

« Hide

MRAYLDLLQH ILDNGGDKGD RTGTGTRSVF GHQMRFDLSK GFPLLTTKKV    50
HFRSIVIELL WFLKGDTNVK YLQDNKVTIW DEWATAEQTA RFGRPEHELG 100
PVYGHQWRNF GATKNADGTY NQDGFDQIKW LINEIKTNPN SRRLIVSGWN 150
PNEAGQVALP PCHTLFQFFV QDNKLSCQLY QRSADVFLGV PFNIASYALL 200
THMIAQVCGL GVGDFVWTGG DTHLYANHFE QAKLQLTREP LPLCQLKLNP 250
EVKDIFDFKF EDIEIVGYES HPAIKAPVAV 280
Length:280
Mass (Da):31,826
Last modified:February 10, 2009 - v1
Checksum:i4BC33ECB88E38F86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001182 Genomic DNA. Translation: ACJ39962.1.
RefSeqiYP_002317945.1. NC_011586.1.

Genome annotation databases

EnsemblBacteriaiACJ39962; ACJ39962; AB57_0541.
GeneIDi7044962.
KEGGiabn:AB57_0541.
PATRICi20694895. VBIAciBau111166_0532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001182 Genomic DNA. Translation: ACJ39962.1 .
RefSeqi YP_002317945.1. NC_011586.1.

3D structure databases

ProteinModelPortali B7I4U0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 480119.AB57_0541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ39962 ; ACJ39962 ; AB57_0541 .
GeneIDi 7044962.
KEGGi abn:AB57_0541.
PATRICi 20694895. VBIAciBau111166_0532.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci ABAU480119:GHQY-553-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AB0057.

Entry informationi

Entry nameiTYSY_ACIB5
AccessioniPrimary (citable) accession number: B7I4U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi